Maternal high‐fat diet promotes onset of diabetes in rat offspring |
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| Authors: | Takeshi Ohta Yasufumi Toriniwa Naruhiko Ryumon Nobuhiro Inaba Tadaaki Hirao Saori Yamanaka Takayuki Maeno Wakako Sakakibara Morio Sumikawa Kaoru Chiba Akiko Nakamura Katsuhiro Miyajima Fatchiyah Fatchiyah Takahisa Yamada |
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| Affiliation: | 1. Japan Tobacco Inc., Central Pharmaceutical Research Institute, Takatsuki, Osaka, Japan;2. Department of Biology, Faculty of Mathematics and Natural Sciences, Brawijaya University, Malang, East Java, Indonesia;3. JT Creative Cervice Co., Ltd., Takatsuki office, Takatsuki, Osaka, Japan;4. Laboratory of Animal Genetics, Graduate School of Science and Technology, Niigata University, Niigata, Japan |
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| Abstract: | The onset and progression of type II diabetes is closely related to environmental factors, in particular dietary habit. Moreover, the environmental exposures very early in life can influence the risk for development of type II diabetes later in life. In this study, we investigated pathophysiological changes in the pups of maternal Spontaneously Diabetic Torii (SDT) rats that were fed a high‐fat diet (HFD) throughout gestation and lactation. Maternal SDT rats were continued on HFD for 5 weeks, from day 8 of gestation to day 21 after birth, and biological analyses of the pups were performed from 2 to 22 weeks of age. Results of serum lipid levels in pups from dams fed HFD were higher than pups from dams fed a standard diet, and the onset of diabetes was significantly accelerated in pups from dams fed HFD. In pathological analyses, pups from dams fed HFD showed increases in liver weight and vacuolation of hepatic cells at 2 weeks of age. In conclusion, the metabolic disorder of lipids and glucose in SDT rats is closely related to the nutritional condition of dams during the periods of gestation and lactation. |
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| Keywords: | diabetic model high‐fat diet SDT rat |
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