| 中性粒细胞胞外诱捕网与病原体的相互作用及其机制 |
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| 引用本文： | 许李锋,张宝戈,洪锦旋,王绪辉,陈吉龙,李训良. 中性粒细胞胞外诱捕网与病原体的相互作用及其机制[J]. 中国畜牧兽医, 2021, 48(4): 1388-1395. DOI: 10.16431/j.cnki.1671-7236.2021.04.026 |
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| 作者姓名： | 许李锋 张宝戈 洪锦旋 王绪辉 陈吉龙 李训良 |
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| 作者单位： | 1. 福建农林大学动物科学学院(蜂学学院), 闽台动物病原生物学福建省高校重点实验室, 福州 350002;2. 中国科学院微生物研究所, 中国科学院病原微生物与免疫学重点实验室, 北京 100101 |
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| 基金项目： | 福建省自然科学基金(2020J05025)。 |
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| 摘 要： | 中性粒细胞作为机体天然免疫系统的重要组成部分,发挥至关重要的防御病原体感染的作用。中性粒细胞发挥防御作用的机制之一是通过释放中性粒细胞胞外诱捕网（neutrophil extracellular traps,NETs）捕获并消灭病原体。然而有些病原体已进化出逃避NETs的机制,从而对机体造成持续损伤。此外,NETs的异常状态也会对机体造成一些损伤。近年来,NETs已成为中性粒细胞功能研究的热点,受到了国内外学者的广泛关注。有学者在禽的异嗜性粒细胞中也发现了类似NETs功能的网状结构,并将其命名为异嗜性粒细胞胞外诱捕网（heterophil extracellular traps,HETs）。作者主要对NETs抵御病原体入侵和病原体逃避NETs的机制并引起宿主致病等过程进行综述。
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| 关 键 词： | 中性粒细胞胞外诱捕网(NETs) 病原体 免疫逃避 免疫损伤 |
| 收稿时间： | 2020-09-01 |
Interaction Between Neutrophil Extracellular Traps and Pathogens and Its Underlying Mechanism |
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| XU Lifeng,ZHANG Baoge,HONG Jinxuan,WANG Xuhui,CHEN Jilong,LI Xunliang. Interaction Between Neutrophil Extracellular Traps and Pathogens and Its Underlying Mechanism[J]. China Animal Husbandry & Veterinary Medicine, 2021, 48(4): 1388-1395. DOI: 10.16431/j.cnki.1671-7236.2021.04.026 |
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| Authors: | XU Lifeng ZHANG Baoge HONG Jinxuan WANG Xuhui CHEN Jilong LI Xunliang |
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| Affiliation: | 1. Key Laboratory of Animal Pathogenic Biology in Fujian and Taiwan, College of Animal Sciences(Bee Learning Institute), Fujian Agriculture and Forestry University, Fuzhou 350002, China;2. CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China |
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| Abstract: | As an important component of innate immune system,neutrophils play a critical role in defense against infection with pathogens.One of the mechanisms by which neutrophils play a defensive role is to capture and destroy pathogens by releasing neutrophil extracellular traps(NETs).However,some pathogens have evolved the escaping mechanisms,and cause a persistent damage in organism.In addition,abnormal NETs can also lead to an organism damage.Recently,NETs has become a focus of research in neutrophil function,and has been widely studied worldwide.Some researchers have found that the reticular structure released from avian heterophiles is similar to that of mammalian NETs,and named it heterophil extracellular traps(HETs).In this review,the authors summarized the mechanisms by which NETs resist pathogen invasion and pathogens escape from NETs,and the pathogenesis caused by interaction between NETs and pathogens. |
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| Keywords: | neutrophil extracellular traps(NETs) pathogens immune escape immune damage |
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