Failure of a Subunit Bovine Herpesvirus 1 Vaccine to Protect Against Experimental Respiratory Disease in Calves |
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| Authors: | C. le Q. Darcel and K.W.F. Jericho |
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| Abstract: | In two experiments in which 31 calves were used, a bovine herpesvirus 1 subunit vaccine previously shown to elicit a strong immunological response in adult cattle failed to do so in younger animals and failed to protect against pneumonia caused by sequential exposure to virulent bovine herpesvirus 1 and Pasteurella haemolytica aerosols. One of the experimental groups had been previously inoculated with a live commercial vaccine but even this failed to elicit a strong immunological response. These results indicate that the calves were in a refractory state when immunized and may explain why similar vaccine failures occur in the field. |
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