Primary bilateral corneal nerve sheath neoplasm in a dog |
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| Authors: | Marina L. Leis M. Elyse Salpeter Bianca S. Bauer Dale L. Godson Bruce H. Grahn |
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| Affiliation: | 1. Department of Small Animal Clinical Sciences, Western College of Veterinary Medicine, University of Saskatchewan, Saskatoon, SK, Canada;2. Prairie Diagnostic Services, Western College of Veterinary Medicine, University of Saskatchewan, Saskatoon, SK, Canada |
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| Abstract: | A 15‐year‐old, neutered male, Shih Tzu cross developed progressive corneal stromal thickening and vascularization of the right eye, and 5 months later, of the left eye. Both eyes became blind due to extensive corneal opacification and were enucleated. Light microscopic examination revealed a diffuse corneal infiltrate of neoplastic mesenchymal cells, and immunohistochemistry revealed diffuse cytoplasmic vimentin immunoreactivity and variable cytoplasmic and nuclear immunoreactivity for S100 in the neoplastic cells. Transmission electron microscopy revealed desmosomes between contiguous cells, thread‐like cytoplasmic processes coated with basement membrane, extracellular bundles of collagen, and axonal degeneration consistent with features of a nerve sheath neoplasm. This is the first report of primary, bilateral corneal nerve sheath sarcoma in a canine. |
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| Keywords: | canine corneal neoplasia electron microscopy histopathology immunohistochemistry nerve sheath neoplasm |
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