Identifying the complex genetic architecture of growth and fatness traits in a Duroc pig population |
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| Authors: | Zhe ZHANG Zi-tao CHEN Shu-qi DIAO Shao-pan YE Jia-ying WANG Ning GAO Xiao-long YUAN Zan-mou CHEN Hao ZHANG Jia-qi LI |
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| Affiliation: | Guangdong Provincial Key Lab of Agro-Animal Genomics and Molecular Breeding/National Engineering Research Center for Breeding Swine Industry/College of Animal Science, South China Agricultural University, Guangzhou 510642, P.R.China |
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| Abstract: | In modern pig breeding programs, growth and fatness are vital economic traits that significantly influence porcine production. To identify underlying variants and candidate genes associated with growth and fatness traits, a total of 1 067 genotyped Duroc pigs with de-regressed estimated breeding values(DEBV) records were analyzed in a genome wide association study(GWAS) by using a single marker regression model. In total, 28 potential single nucleotide polymorphisms(SNPs) were associated with these traits of interest. Moreover, VPS4 B, PHLPP1, and some other genes were highlighted as functionally plausible candidate genes that compose the underlying genetic architecture of porcine growth and fatness traits. Our findings contribute to a better understanding of the genetic architectures underlying swine growth and fatness traits that can be potentially used in pig breeding programs. |
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| Keywords: | pig GWAS growth trait fatness trait candidate gene |
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