| 中链脂肪酸抗菌和诱导防御肽表达的功能及其在仔猪饲料中的应用 |
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| 引用本文： | 喻正旺,周忠新. 中链脂肪酸抗菌和诱导防御肽表达的功能及其在仔猪饲料中的应用[J]. 中国农业科学, 2021, 54(13): 2895-2905. DOI: 10.3864/j.issn.0578-1752.2021.13.017 |
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| 作者姓名： | 喻正旺 周忠新 |
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| 作者单位： | 农业动物遗传育种与繁殖教育部重点实验室/生猪健康养殖协同创新中心/华中农业大学动物营养与饲料科学系,武汉 430070 |
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| 基金项目： | “十三五”国家重点研发计划(2016YFD0501210);中央高校基本科研业务费专项基金资助(2662018BY017) |
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| 摘 要： | 近年,越来越多的研究表明,中链脂肪酸（MCFAs）抵抗病原菌是哺乳动物先天防御系统的重要组成部分,而且MCFAs也能够诱导人、猪和鸡内源性防御肽的表达,MCFAs的这些新功能尚未引起重视。MCFAs还和饲用有机酸或饲用植物精油具有协同抗菌增效作用,可以减少这些活性物质的使用量。相比于长链脂肪酸,日粮中添加MCFAs能显著地提高动物机体内氧气消耗量和线粒体呼吸速率,但产生活性氧自由基少,特别适合幼龄动物肠代谢和肝代谢所需的快速能量供应特点。日粮添加低浓度MCFAs（0.1%—0.5%,质量比）能显著提高新生或断奶仔猪存活率、粗蛋白粗脂肪消化率、饲料转化率,调节肠道菌群和改善肠上皮结构,进而促进生长。基于MCFAs的上述功能,将MCFAs与饲用有机酸或植物精油复配制备成微囊颗粒,可能是其用于仔猪抗生素替代品的尚佳方式。
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| 关 键 词： | 中链脂肪酸 先天防御系统 协同抗菌 防御肽 仔猪 |
| 收稿时间： | 2020-05-31 |
Functions of Antibacterial and Inducing Defense Peptide Expression of Medium-Chain Fatty Acid and Its Application in Piglet Feeds |
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| YU ZhengWang,ZHOU ZhongXin. Functions of Antibacterial and Inducing Defense Peptide Expression of Medium-Chain Fatty Acid and Its Application in Piglet Feeds[J]. Scientia Agricultura Sinica, 2021, 54(13): 2895-2905. DOI: 10.3864/j.issn.0578-1752.2021.13.017 |
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| Authors: | YU ZhengWang ZHOU ZhongXin |
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| Affiliation: | Key Lab of Agricultural Animal Genetics/Breeding and Reproduction of Ministry of Education/Department of Animal Nutrition and Feed Science, Huazhong Agriculture University, Wuhan 430070 |
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| Abstract: | In recent years, more and more studies have shown that medium-chain fatty acid (MCFAs) resistance to pathogenic bacteria is an important component of innate defense system of mammals, and MCFAs can also induce expressions of endogenous host defense peptides (HDPs) in human, pig and chicken. However, these new functions of MCFAs have not attracted much attention. MCFAs also have a synergistic antibacterial synergistic effect with feeding organic acids or feeding plant essential oils, which can reduce the use of these active substances. In addition, compared with long-chain fatty acids, the addition of MCFAs in the diet can significantly increase the oxygen consumption and mitochondrial respiration rate in the body of animals, but it produces less reactive oxygen species, which is in line with the characteristics of rapid energy supply required by intestinal metabolism and liver metabolism in young animals. Adding low concentration of MCFAs (0.1%-0.5%, mass ratio) to the diet can significantly increase the survival rate of newborn or weaned piglets, the digestibility of crude protein and crude fat as well as the feed conversion rate, regulate the intestinal flora, and improve the intestinal epithelial structure, thus promoting the growth of animals. Based on the above advantages of MCFAs, mixing MCFAs with forage organic acid or plant essential oil to prepare coated particles may be a good way to use it as a substitute for antibiotics in piglets. |
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| Keywords: | medium chain fatty acid innate defense system host defense peptide synergistic antibiotics piglets |
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