Efficacy and side effects of radiation therapy in comparison with radiation therapy and temozolomide in the treatment of measurable canine malignant melanoma |
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| Authors: | S. Cancedda C. Rohrer Bley L. Aresu M. Dacasto V. F. Leone S. Pizzoni M. Gracis L. Marconato |
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| Affiliation: | 1. Centro Oncologico Veterinario, Sasso Marconi, Italy;2. Division of Radiation Oncology, Vetsuisse‐Faculty, University of Zurich, Zurich, Switzerland;3. Department of Comparative Biomedicine and Food Science, University of Padua, Legnaro, Italy;4. Clinica Veterinaria San Siro, Milan, Italy |
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| Abstract: | Prognosis for unresectable canine malignant melanoma (MM) is typically poor, and therapeutic approaches remain largely palliative. A bi‐institutional trial was conducted to compare efficacy and safety of radiation therapy (RT) and RT with post‐radiation temozolomide in dogs with chemotherapy‐naïve, measurable MM. RT consisted of 5 × 6 Gy fractions over 2.5 weeks. Dogs whose owners wished to pursue chemotherapy received adjuvant oral temozolomide (60 mg m?2 for 5 days every 28 days). Fifteen dogs were treated with RT only (Group 1) and 12 dogs subsequently received temozolomide (Group 2). Overall response rate was similar between Group 1 (86.7%) and Group 2 (81.1%). Median time to progression (TTP) was significantly longer in Group 2 (205 days) compared to Group 1 (110 days; p = 0.046). Survival time was not significantly different between groups. Both treatments were well tolerated. Post‐radiation temozolomide has a good safety profile, and may improve TTP in MM when compared to coarse fractionated RT. |
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| Keywords: | dog malignant melanoma radiation therapy temozolomide |
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