| 外源性H2S对氯胺酮全麻大鼠主要生理指标的影响 |
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| 引用本文： | 李妍,唐琦超,时静,刘海玉,姜胜,白春杨,白鸽,赵越,范宏刚. 外源性H2S对氯胺酮全麻大鼠主要生理指标的影响[J]. 中国畜牧兽医, 2014, 41(9): 150-154 |
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| 作者姓名： | 李妍 唐琦超 时静 刘海玉 姜胜 白春杨 白鸽 赵越 范宏刚 |
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| 作者单位： | 东北农业大学动物医学学院, 黑龙江哈尔滨 150030 |
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| 基金项目： | 国家自然科学基金（31001092）；高等学校博士学科点专项科研基金（20102325120016）；黑龙江省教育厅科学技术研究项目（12521003）；黑龙江省普通高等学校重点试验室开放课题资助项目（yy-2012-11、mz-2012-10）；东北农业大学大学生创新创业训练计划项目（2013026）。 |
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| 摘 要： | 外源性H2S在诸多方面对中枢神经系统具有保护性作用，本研究通过预试验确定了外源性H2S的给药时间和剂量，将48只SD大鼠随机均分为4组，分别为对照组（CP组）、低剂量组（LP组，7 μmol/kg NaHS）、中剂量组（MP组，14 μmol/kg NaHS）、高剂量组（GP组，28 μmol/kg NaHS）。在盐酸氯胺酮麻醉前20 min，3个剂量组分别腹腔注射7、14、28 μmol/kg NaHS，观察外源性H2S对大鼠体温、心率、呼吸频率、血氧饱和度及血压等生理指标的干预效果。试验结果表明，与对照组相比，3个剂量组体温和血氧饱和度浓度均显著升高（P<0.05），心率和血压均显著降低（P<0.05），但呼吸频率呈先减慢后加快趋势，且这些变化呈显著的剂量依赖性。
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| 关 键 词： | 外源性H2S 氯胺酮 麻醉 生理指标 |
| 收稿时间： | 2014-01-09 |
Effects of Exogenous H2S on the Main Physiological Parameters in Rats Anesthetized with Ketamine |
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| LI Yan,TANG Qi-chao,SHI Jing,LIU Hai-yu,JIANG Sheng,BAI Chun-yang,BAI Ge,ZHAO Yue,FAN Hong-gang. Effects of Exogenous H2S on the Main Physiological Parameters in Rats Anesthetized with Ketamine[J]. China Animal Husbandry & Veterinary Medicine, 2014, 41(9): 150-154 |
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| Authors: | LI Yan TANG Qi-chao SHI Jing LIU Hai-yu JIANG Sheng BAI Chun-yang BAI Ge ZHAO Yue FAN Hong-gang |
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| Affiliation: | College of Veterinary Medicine, Northeast Agricultural University, Harbin 150030, China |
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| Abstract: | Exogenous H2S, in many aspects, had a protective effect on the central nervous system. In preliminary experiment, the administration time and dosage of exogenous H2S were determined, and then 48 SD rats were randomly divided into four groups, such as control group (CP group), low-dose group (LP group, 7 μmol/kg NaHS), middle-dose group (MP group, 14 μmol/kg NaHS), high-dose group (GP group, 28 μmol/kg NaHS). Animals in three dose groups were randomly administrated 7, 14, 28 μmol/kg NaHS by intraperitoneal injection, followed the administration of ketamine 20 minutes after. The body temperature, heart rate, respiratory rate, blood oxygen saturation and blood pressure were recorded. The results showed that compared to the CP group,body temperatures and blood oxygen saturations in the dose groups significantly increased (P<0.05), heart rates and blood pressures in the dose groups significantly decreased (P<0.05), respiratory rates in the dose groups slowed down, followed a tendency to increase, and these changes showed a significant dose-dependent. |
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| Keywords: | exogenous H2S ketamine anesthesia physiological parameters |
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