| 中药有效成分对细菌溶血素的抑制作用 |
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| 引用本文： | 黄程程,孙磊,张泽辉,张鹏,张德显,刘明春. 中药有效成分对细菌溶血素的抑制作用[J]. 中国畜牧兽医, 2016, 43(12): 3363-3367. DOI: 10.16431/j.cnki.1671-7236.2016.12.041 |
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| 作者姓名： | 黄程程 孙磊 张泽辉 张鹏 张德显 刘明春 |
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| 作者单位： | 沈阳农业大学畜牧兽医学院, 沈阳 110866 |
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| 基金项目： | 国家自然科学基金（31201954、31572564） |
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| 摘 要： | 在防制细菌性疾病方面，抗菌药物起着非常重要的作用，但是随着抗菌药物在临床上的广泛应用，细菌的耐药问题日益突出，给临床治疗带来极大困难。近年来，以中药抑制细菌毒力因子控制细菌感染的治疗策略已引起国内外学者的广泛关注。细菌溶血素是细菌产生的主要毒力因子之一，随着研究的不断深入，开发溶血素抑制剂成为解决细菌感染问题的关键。现针对中药对细菌溶血素的抑制作用进行综述，以期为临床治疗细菌性疾病提供理论依据。
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| 关 键 词： | 中药 有效成分 溶血素 细菌 抑制作用 |
| 收稿时间： | 2016-05-27 |
Review on the Prohibitive Effect of Gradients in Chinese Traditional Herbs on Hemolysin in Bacteria |
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| HUANG Cheng-cheng,SUN Lei,ZHANG Ze-hui,ZHANG Peng,ZHANG De-xian,LIU Ming-chun. Review on the Prohibitive Effect of Gradients in Chinese Traditional Herbs on Hemolysin in Bacteria[J]. China Animal Husbandry & Veterinary Medicine, 2016, 43(12): 3363-3367. DOI: 10.16431/j.cnki.1671-7236.2016.12.041 |
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| Authors: | HUANG Cheng-cheng SUN Lei ZHANG Ze-hui ZHANG Peng ZHANG De-xian LIU Ming-chun |
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| Affiliation: | College of Animal Husbandry and Veterinary Medicine, Shenyang Agricultural University, Shenyang 110866, China |
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| Abstract: | Antimicrobial agents play a crucial role in the prevention and treatment of bacterial diseases. However, the widely clinical use of antibiotics makes the bacteria antibiotic-resistance problem much more severe, which could increase the difficulty of clinical treatment. Recently, the method of using traditional Chinese herbs to control bacterial infection by suppressing the bacterial virulence factors has got researchers'attention around the world. Hemolysin is one of the crucial virulence factors in many kinds of bacteria, therefore hemolysin is an ideal target to combat the infection caused by bacteria. The suppressing effect of Chinese herbs to the hemolysin is synthesized and reviewed here to lay theoretical foundation for the clinical treatment of bacterial diseases. |
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| Keywords: | Chinese traditional herbs effective gradient hemolysin bacteria prohibitive effect |
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