| 类噻唑烷酮离子阻断剂药物毒理学安全性评价 |
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| 引用本文： | 刘国章,胡士峰,孔江南,李晓翠,张晓梅,郭准,李宏基,杨国宇. 类噻唑烷酮离子阻断剂药物毒理学安全性评价[J]. 中国畜牧兽医, 2013, 40(6): 174-177 |
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| 作者姓名： | 刘国章 胡士峰 孔江南 李晓翠 张晓梅 郭准 李宏基 杨国宇 |
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| 作者单位： | 河南农业大学牧医工程学院, 河南郑州 450002 |
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| 摘 要： | 本研究对实验室合成的一种用于治疗动物腹泻的药物囊性纤维化跨膜传导调节因子(cystic fibrosis transmembrane conductance regulator,CFTR)抑制剂——类噻唑烷酮进行了毒理学安全性评价。将受试物通过灌胃给予试验动物,通过全身毒性试验、小鼠精子致变试验、小鼠骨髓嗜多染红细胞微核试验和Ames试验进行安全性评价。结果显示,受试物没有全身急性毒性;在体内没有对生殖细胞致突变作用;不会对染色体和细胞有丝分裂造成损伤;没有诱变性。本研究为进一步将该类噻唑烷酮应用于治疗仔猪腹泻提供可靠的试验依据。
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| 关 键 词： | 类噻唑烷酮离子阻断剂药物 毒理学 评价 |
| 收稿时间： | 2012-10-21 |
The Toxicological Safety Assessment of Thiazlidone-like Channel Blocker Drug |
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| LIU Guo-zhang,HU Shi-feng,KONG Jiang-nan,LI Xiao-cui,ZHANG Xiao-mei,GUO Zhun,LI Hong-ji,YANG Guo-yu. The Toxicological Safety Assessment of Thiazlidone-like Channel Blocker Drug[J]. China Animal Husbandry & Veterinary Medicine, 2013, 40(6): 174-177 |
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| Authors: | LIU Guo-zhang HU Shi-feng KONG Jiang-nan LI Xiao-cui ZHANG Xiao-mei GUO Zhun LI Hong-ji YANG Guo-yu |
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| Affiliation: | College of Animal Husbandry and Veterinary Engineering, Henan Agricultural University, Zhengzhou 450002, China |
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| Abstract: | It was reported that the toxicological safety assessment of a CFTR inhibitor.It was about thiazlidone-like channel blocker drug which synthesized in laboratory, and used in the treatment of animals diarrhea.Drug was given to mice by intragastric administration.Toxicological assessment test of thiazlidone-like channel blocker drug inclued systemic toxicity test,mouse sperm malformation test,bone marrow micronucleus test and Ames test. Results showed that the drug had no acute systemic toxicity, no mutagenic action on germ cells in vivo, no damage on chromosomes and cell mitosis and no mutagenicity. Results provided reliable test basis to use the drug further which could be used to treat diarrhea of piglets. |
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| Keywords: | thiazlidone-like channel blocker drug toxicology assessment |
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