| 复方利福昔明纳米乳的制备及质量评价 |
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| 引用本文： | 边益庆,高娴. 复方利福昔明纳米乳的制备及质量评价[J]. 畜牧与饲料科学, 2018, 39(4): 1-1. DOI: 10.12160/j.issn.1672-5190.2018.04.001 |
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| 作者姓名： | 边益庆 高娴 |
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| 作者单位： | [1]榆林市动物疫病预防控制中心,陕西榆林719000 |
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| 摘 要： | 旨在制备复方利福昔明纳米乳,并对其理化性质进行评价。以纳米乳的载药量、稳定性为考查指标,筛选油相、表面活性剂、助表面活性剂;绘制伪三元相图确定最佳配方;利用透射电子显微镜、激光粒度测定仪考查其微观形态和粒径,采用染色法鉴别纳米乳的类型;经光照试验、温度试验、高速离心试验考查纳米乳的稳定性。结果表明,复方利福昔明纳米乳的最佳配方为利福昔明1%、肉桂醛2.44%、聚乙二醇-2004.88%、聚氧乙烯醚-40-蓖麻油19.51%、蒸馏水72.17%;复方利福昔明纳米乳为水包油型(O/W),可以无限稀释;在透射电镜下观察,纳米乳呈圆球形,无粘连,平均粒径为11.8nm;光照试验、温度试验、长期试验显示,纳米乳稳定性良好。复方利福昔明纳米乳制备方法简单,质量可控,为利福昔明广泛应用于畜禽肠道细菌感染的治疗提供了理论依据。
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Preparation and Quality Evaluation of Compound Rifaximin Nanoemulsion |
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| Abstract: | The purpose of this study was to prepare compound rifaximin nanoemulsion and to analyze its physical and chemical properties.Using the drug loading capacity and stability of nanoemulsion as evaluating indexes,the oil phase,surfactant and co-surfactant were selected;the optimum formula was designed using pseudo-ternary phase diagram;the micromorphology and particle size of the nanoemulsion were observed and determined by transmission electron microscopy and laser particle size analyzer,respectively;the type of nanoemulsion was identified by staining test;the stability of nanoemulsion was investigated by light test,temperature test and high-speed centrifugation test.The results showed that the optimal formula of the compound rifaximin nanoemulsion was rifaximin 1%,cinnamaldehyde 2.44%,polyethylene glycol-200 4.88%,polyoxyethylene ether-40-castor oil 19.51%and distilled water 72.17%;the compound rifaximin nanoemulsion was oil-in-water(O/W)type and could be diluted infinitely;under transmission electron microscope,the nanoemulsion particle was spherical and had no adhesions,with the average particle size of 11.8 nm;the nanoemulsion had good stability.It is indicated that the preparation of compound rifaximin nanoemulsion is simple and the quality of the product is controllable.Our results provide a theoretical basis for the wide use of compound rifaximin in the treatment of intestinal bacterial infections in livestock and poultry. |
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