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| 黄芪多糖对力竭游泳小鼠生理生化指标的影响 | |
| 引用本文： | 彭涛,李文平,张明军,肖定福,苏丁丁,伍勇,李荣芳. 黄芪多糖对力竭游泳小鼠生理生化指标的影响[J]. 中国畜牧兽医, 2008, 35(12): 33-36 |
| 作者姓名： | 彭涛 李文平 张明军 肖定福 苏丁丁 伍勇 李荣芳 |
| 作者单位： | .湖南农业大学动物医学院， 长沙 410128； 2.湖南农业大学动物科技学院， 长沙 10128 |
| 基金项目： | 湖南省教育厅资助项目 |
| 摘 要： | 用不同剂量的黄芪多糖给小鼠灌胃（0.4、0.2、0.1 mg/ml），力竭游泳后测定其13项血液生理指标，肝脏和心脏的超氧化物歧化酶（SOD）、谷胱甘肽过氧化物酶（GSH Px）、过氧化氢酶(CAT)及血清谷丙转氨酶（AST）、谷草转氨酶（ALT）、肌酸激酶（CK）的活性。结果表明，高剂量组可极显著延长小鼠游泳至力竭的时间（P<0.01），中剂量组可显著延长小鼠游泳至力竭的时间（P<0.05）；高剂量组白细胞总数（WBC）、粒细胞百分数（Gran%）极显著低于对照组（P<0.01），淋巴细胞百分数（Lym%）、中值细胞百分数（Mid%）、粒细胞数（Gran）极显著高于对照组（P<0.01），高、中剂量组血红蛋白浓度（HGB）、红细胞压积（HCT）极显著高于对照组（P<0.01）；中剂量组淋巴细胞百分数（Lym%）、中值细胞百分数（Mid%）显著高于对照组（P<0.05）；高剂量组极显著提高力竭小鼠肝、心组织SOD、CAT的活性，极显著降低心、肝组织GSH Px（P<0.01）；中剂量组显著提高力竭小鼠肝、心组织SOD的活性（P<0.05）；高、中剂量组血清AST、CK的活性极显著降低（P<0.01）。由此可见，黄芪多糖具有明显的抗氧化损伤功效。 |
| 关 键 词： | 黄芪多糖 力竭游泳小鼠 生理生化指标 |
Effect of Astragalus Polysaccharide on Physiological and Biochemical Indexes in Exhausted Swimming Mice |
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| PENG Tao,LI Wen-ping,ZHANG Ming-jun,XIAO Ding-fu,SU Ding-ding,WU Yong,LI Rong-fang. Effect of Astragalus Polysaccharide on Physiological and Biochemical Indexes in Exhausted Swimming Mice[J]. China Animal Husbandry & Veterinary Medicine, 2008, 35(12): 33-36 | |
| Authors: | PENG Tao LI Wen-ping ZHANG Ming-jun XIAO Ding-fu SU Ding-ding WU Yong LI Rong-fang |
| Affiliation: | 1. College of Animal Medical , Hunan Agricultural University, Changsha, 410128, China;2.College of Animal Science and Technology,Hunan Agricultural University, Changsha, 410128, China |
| Abstract: | Pouring different dosages of APS(0.4,0.2,0.1 mg/ml)to exhausted swimming mice's stomach,we analysed blood component and tested the activities of SOD,GSH-Px,CAT.The results showed that the time of swim to exhaust in the high-dose group was extremely remarkably prolonged(P<0.01),and that in the middle dose group was significantly prolonged(P<0.05);the total number of WBC,Gran% in the high-dose group were significantly lower than those in the control group(P<0.01),Lym%,Mid% and Gran were very significantly higher than those in the control group(P<0.01),the concentration of HGB and HCT in the high-dose group and sino-dose group were very significantly higher than those in the control group(P<0.01);Lym% and Mid% in the sino-dose group were significantly higher than those in the control group(P<0.05);the activity of SOD and CAT were significantly increased in the high-dose group and the activity of GSH-PX was very significant decreased(P<0.01);the activity of SOD in the sino-dose group was significantly increased(P<0.05);the activity of AST and CK in the high-dose group and sino-dose group were very significantly decreased(P<0.01).Thus,APS has obvious oxidative damage effects. |
| Keywords: | APS exhausted swimming mice physiological and biochemical indexes |
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