气相色谱－质谱法测定猪尿中地西泮

建立了猪尿中地西泮的气相色谱-质谱（GC／MS）检测方法。样品经C18固相萃取柱净化后进行气相色谱-质谱测定。结果表明，方法定量限为0．5μg/L，线性范围为10～500μg/L。在三个添加浓度2、4、6μg/L水平上，地西泮的平均回收率为70％～120％，批内相对标准偏差〈20％、批间相对标准偏差〈12％。

Determination of Diapazem in Swine Urine by Gas Chromatography - Mass Spectrometry

A gas chromatography- mass spectrometric （GC/MS） method has been established for the determination of diapazem in swine urine. The samples were cleaned up on C18 cartridge, and detected by GC/MS. The results indicated that the limit of quantification （ LOQ ） was 0.5μg/L, and the linearity was within the range of 10 -500 μg/L. The mean recovery of swine urine samples fortified at three levels of 2,4 and 6 μg/L was within the range of 70% - 120%, intra - batch relative standard deviation was less than 20%, and inter - batch relative standard deviation was less than 12%.