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乳酸恩诺沙星对小鼠的急性毒性试
引用本文:唐一鸣.乳酸恩诺沙星对小鼠的急性毒性试[J].中国兽药杂志,2010,44(4):29-30.
作者姓名:唐一鸣
作者单位:浙江大学动物科学学院
基金项目:国家蛋鸡产业技术体系项目 (NYCYFX-g09)
摘    要:采用新药乳酸恩诺沙星测定了其对实验小鼠的半数致死量(LD50), 为其可溶性粉开展药效试验提供依据。按照农业部关于一般毒性试验及临床试验规范进行试验。结果表明, 乳酸恩诺沙星对小白鼠灌胃染毒及腹腔注射染毒的 LD50分别为3579 mg/kg,和571.3 mg/kg,其95%可信限分别为3011~4255 mg/kg和498.3~655.1 mg/kg。研究提示, 乳酸恩诺沙星属低毒物质,其可溶性粉能用于开展药效试验。

关 键 词:乳酸恩诺沙星  小鼠  急性毒性
收稿时间:2009/12/28 0:00:00
修稿时间:2/8/2010 12:00:00 AM

Acute toxicity of enrofloxacin lactate in mice
Tang Yiming.Acute toxicity of enrofloxacin lactate in mice[J].Chinese Journal of Veterinary Drug,2010,44(4):29-30.
Authors:Tang Yiming
Institution:College of Animal Sciences Zhejiang University
Abstract:The acute toxicity test in mice was studied. LD50 values and its 95% confidence limits were calculated according to Karber method. The results showed that the LD50 of enrofloxacin lactate in mice ig and ip was 3579 and 571.3 mg/kg.bw, its 95% confidence limits were between 3011 mg/kg and 4255 mg/kg, 498.3 mg/kg and 655.1 mg/kg, respectively. We conclude that enrofloxacin lactate is a safe antibacterial agent with low toxicity, and it can be used in the following efficacy test.
Keywords:enrofloxacin lactate  mice  acute toxicity
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