| 氟苯尼考可溶性粉的研制及溶出度测定 |
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| 引用本文： | 刘永琼,祝宏,王尧,李平云,李从强.氟苯尼考可溶性粉的研制及溶出度测定[J].中国兽药杂志,2004,38(10):8-12. |
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| 作者姓名： | 刘永琼 祝宏 王尧 李平云 李从强 |
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| 作者单位： | 武汉化工学院药物制剂及天然药物研究室,湖北武汉,430073 |
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| 摘 要： | 选择低聚糖类辅料A并利用喷雾干燥法制备氟苯尼考可溶性粉.取氟苯尼考100 g,辅料A 900 g,喷雾干燥制成规格为50 g∶ 5 g的氟苯尼考粉剂.喷雾干燥得到的可溶性粉的溶出速率和溶出百分率明显高于物混物,其溶出率为99.05%,分别是氟苯尼考原料干燥品(溶出率30.34%)和氟苯尼考原粉(溶出率2.35%)的3.26倍和42.15倍,使氟苯尼考的水溶性大大提高.
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| 关 键 词： | 氟苯尼考 喷雾干燥 可溶性粉 紫外分光光度法 溶出度 |
| 文章编号： | 1002-1280(2004)10-0008-05 |
Preparation of florfenicol soluble powder and determination of its dissolution |
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| LIU Yong-qiong,ZHU Hong,WANG Yao,LI Ping-yun,LI Cong-qiang.Preparation of florfenicol soluble powder and determination of its dissolution[J].Chinese Journal of Veterinary Drug,2004,38(10):8-12. |
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| Authors: | LIU Yong-qiong ZHU Hong WANG Yao LI Ping-yun LI Cong-qiang |
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| Abstract: | Florfenicol soluble powder was made with 100 grams florfenicol and 900 grams accessory material (a kind of oligosaccharides) by spray-drying. The dissolution rate and solubility of the product were better than those of raw florfenicol and the physical mixture. The dissolution of the former was 99.05% while the latter were (2.35% )and 30.34% respectively. The solubility of florfenicol is improved remarkably. |
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| Keywords: | florfenicol spray-dring soluble powder dissolution |
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