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猪乙型脑炎减毒活疫苗的安全性和免疫原性试验
引用本文:徐涤平,刘泽文,杨宜生,熊忠良,段正赢,邵华斌,贾丽丽,俞永新.猪乙型脑炎减毒活疫苗的安全性和免疫原性试验[J].中国兽药杂志,2002,36(8):20-22.
作者姓名:徐涤平  刘泽文  杨宜生  熊忠良  段正赢  邵华斌  贾丽丽  俞永新
作者单位:1. 湖北省农业科学院畜牧兽医研究所,湖北,武汉,430209
2. 中国药品生物制品检定所,北京,100050
摘    要:将猪用JEV减毒株SA14-14-2VS制备的活疫苗脑内注射3周龄小白鼠,不能使小鼠致病。用不同剂量活苗注射后备母猪,均未出现任何不良的临床反应。用后备母猪进行免疫原性试验,能产生良好的免疫应答。免疫该疫苗的初产母猪能抵抗JEV强毒的攻击,不产生病毒血症,对胎儿感染的保护率达100%。因此,该减毒活疫苗具有可靠的安全性,良好的免疫原性。

关 键 词:猪乙型脑炎  减毒活疫苗  安全性  免疫效力
文章编号:1002-1280(2002)08-0020-03
修稿时间:2001年8月20日

Safety and Immunity Tests of Attenuated Japanese B. Encephalitis Live-vaccine Used for Swine
XU Di-ping,LIU Ze-wen,YANG Yi-sheng,XIONG Zhong-liang,DUAN Zheng-ying,SHAO Hua-bin,JIA Li-li,YU Yong-xin.Safety and Immunity Tests of Attenuated Japanese B. Encephalitis Live-vaccine Used for Swine[J].Chinese Journal of Veterinary Drug,2002,36(8):20-22.
Authors:XU Di-ping  LIU Ze-wen  YANG Yi-sheng  XIONG Zhong-liang  DUAN Zheng-ying  SHAO Hua-bin  JIA Li-li  YU Yong-xin
Institution:XU Di-ping1,LIU Ze-wen1,YANG Yi-sheng1,XIONG Zhong-liang1,DUAN Zheng-ying1,SHAO Hua-bin1,JIA Li-li2,YU Yong-xin2
Abstract:The attenuated live-vaccine made from the SA14-14-2VS strain was inoculated into the brains of themice and it didnt make the mice sick and die. The vaccine was safe to the replacement gilts when they wereinoculated with different doses, and the gilts had high immunity response. Primiparous gilts inoculated with thevaccine could resist the high pathogenic JEVs attack, and their foetus were all protected. The vaccine was safeand had good immunity.
Keywords:JEV  attenuated live-vaccine  safety  immunity
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