牛磺酸对马杜霉素中毒大鼠的保护作用

观察牛磺酸对大鼠马杜霉素中毒时的保护作用。将试验大鼠每天灌服马杜霉素进行染毒,且染毒前1 h腹腔注射牛磺酸保护,染毒5 d,继续注射牛磺酸2 d后处死,测定血清、肝脏、腿肌和心肌的丙二醛（MDA）含量、超氧化物歧化酶（SOD）活性、谷胱甘肽过氧化物酶（GSH-Px）活力和总抗氧化能力（T-AOC）。结果表明牛磺酸组的大鼠血清、肝脏、腿肌和心肌中SOD活性、GSH-Px活力、T-AOC均有所提高,MDA有所降低,与对照组、马杜霉素组比较,差异显著（P〈0.01,P〈0.05）。牛磺酸可以提高大鼠机体的抗氧化能力,对马杜霉素引起的脂质过氧化具有保护作用。

Protective effects of taurine on toxic rats induced by maduramicin

In order to observe the protective effects of taurine on toxic rats induced by maduramicin. SD rats were given taurine by intraperitoneal injection, and were given maduramicin by oral after 1 hours. Rats were induced by maduramicin for 5 days, but were given by taurine for 7 days. The concentration of MDA, and the activity of SOD, GSH-Px, and T-AOC in serum, liver, skeletal muscle and myocardium were measured respectively. The results show that the activity of SOD, GSH-Px and T-AOC in protected groups by taurine increased and the concentration of MDA decreased significantly (P<0.01, P<0.05) compared with the induced group by maduramicin. Taurine could increase antioxidative effects and reduce lipid peroxidation in toxic rats induced by maduramicin.