| 反式-4-羟基-L-脯氨酸发酵菌株的筛选 |
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| 引用本文： | 李春玲,丁亚莲,谢文静,牛春,张萍.反式-4-羟基-L-脯氨酸发酵菌株的筛选[J].中国兽药杂志,2019,53(1):42-44. |
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| 作者姓名： | 李春玲 丁亚莲 谢文静 牛春 张萍 |
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| 作者单位： | 宁夏泰瑞制药股份有限公司,,,,宁夏泰瑞制药股份有限公司 |
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| 摘 要： | 为选育出反式-4-羟基-L-脯氨酸发酵生产的优良菌株，以8株产反式-4-羟基-L-脯氨酸的大肠杆菌（Escherichia coli）为出发菌株，对其生长特性、发酵效率进行了比较分析，筛选出2株遗传稳定性好、生产效率高的菌株Hyp-Y1801、Hyp-Y1808，其发酵效价分别为50.4 g/L、47.5g/L，对实现反式-4-羟基-L-脯氨酸的工业化生产具有重要意义。
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| 关 键 词： | 反式-4-羟基-L-脯氨酸 发酵菌株 大肠杆菌 筛选 |
| 收稿时间： | 2018/10/17 0:00:00 |
| 修稿时间： | 2019/1/15 0:00:00 |
Screening of fermentation Strain for trans-4-hydroxy-L-proline |
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| Institution: | Ningxia Tairui pharmaceutical Company Limited,,,, |
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| Abstract: | In order to select a good fermentation producing strain of trans-4-hydroxy-L-proline, comparative analysis were made in growth characteristics and production efficiency of 8 strains Escherichia coli producing trans-4-hydroxy-L-proline. Hyp-Y1801 strain and Hyp-Y1805 strain with high inheritance stability and high fermentation efficiency were screened. The fermentation potency of Hyp-Y1801 and Hyp-Y1808 were 50.4 g/L and 47.5 g/L respectively. The result had great significance for industrial production of trans-4-hydroxy-L-proline. |
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| Keywords: | trans-4-hydroxy-L-proline fermentation strain Escherichia coli screening |
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