地美硝唑盐片剂的制备及体外溶出度

采用紫外分光光度法，对用淀粉、糊精和微晶纤维素等辅料制备的地美硝唑盐片剂和未成盐地美硝唑片剂进行了体外溶出度和释药动力学的比较研究。结果表明，在人工肠液中，两者累积释药50％的时间分别为7.59min和18.26min，前者的溶出速率明显快于后者。本品在45min内可溶解80％以上，释药规律符合Weibull方程。

The Preparation and in vitro Dissolution of Dimetridazole Salt Tablets

In vitro dissolution and release kinetics of dimetridazole salt tablets and dimetridazole tablets were tested with UV, both tablets were prepared by starch, dextrin and microcrystalline cellulose, and so on. In manmade intestinal juice,the time for the accumulated drugrelease amount up to 50% of both kinds of tablets were 7.59 min and 18.26 min respectively. Furthermore, release rate in vitro of former was faster than that of the later. The tablet could be dissolved more than 80% in 45 min. The dissolution behavior fitted Weibull' equation.