| 猪FRZB、ABCF1基因多态性与生长性状的关联分析 |
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| 引用本文： | 杨华,徐珍,陈佳,姜佳佳,毛翠,毛慧敏,左波,徐在言.猪FRZB、ABCF1基因多态性与生长性状的关联分析[J].中国畜牧杂志,2018(1). |
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| 作者姓名： | 杨华 徐珍 陈佳 姜佳佳 毛翠 毛慧敏 左波 徐在言 |
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| 作者单位： | 湖北省生猪健康养殖协同创新中心农业部动物遗传育种与繁殖教育部重点实验室农业部猪遗传育种重点实验室华中农业大学;湖北省畜禽育种中心;山东省荣成市俚岛镇俚岛畜牧兽医站;浙江天蓬集团有限公司; |
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| 摘 要： | FRZB基因通过抑制Wnt信号途径调控细胞生长,ABCF1(也称为ABC50)结合e IF2,在翻译起始中发挥着重要的作用,可作为猪生长性状相关的候选基因。本研究采用直接测序法检测FRZB基因和ABCF1基因5'非翻译区中单核苷酸多态性(SNPs)基因型分布,并分析基因型与生长性状的相关性。结果表明:在美系大白猪中,FRZB基因位点ins(A-532G)多态性与背膘厚呈极显著相关(P0.01),与体长接近显著水平(P=0.05);ABCF1基因254A/G多态性与背膘厚、左乳头数和右乳头数均呈显著相关(P0.05);在法系大白中,ABCF1基因254A/G多态性与初生重呈显著相关(P0.05)。结果表明,FRZB和ABCF1基因是潜在的影响猪生长性状的候选基因。
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| 关 键 词： | FRZB ABCF1 多态性 生长性状 关联分析 猪 |
Genetic Polymorphism of FRZB Gene and ABCF1 and Their Association with Growth Traits in Pigs |
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| Institution: | ,The Cooperative Innovation Center for Sustainable Pig Production of Hubei Province, Key Laboratory of Swine Genetics and Breeding, Ministry of Agriculture & Key Laboratory of Agricultural Animal Genetics, Breeding and Reproduction,Ministry of Education, College of Animal Science and Veterinary Medicine, Huazhong Agricultural University,Livestock and Poultry Breeding Center of Hubei Province,Animal Husbandry and Veterin |
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| Abstract: | FRZB gene regulates cell growth by inhibiting Wnt signaling pathway, ABCF1( also known as ABC50: ATPbinding cassette 50) binds to eukaryotic initiation factor 2(e IF2) and is required for efficient translation initiation, so they can be selected as candidate genes for growth trait. In this study, we detected the genotype of two SNPs in 5 ′-UTR of FRZB and ABCF1 gene by sequencing in pig population and analyzed the effects of the genotype on growth traits. The results showed that the locus of A-532 G of FRZB gene in American Large White pigs was significantly associated with back fat thickness(P<0.01), and the body length was closed to significant level(P=0.05). For the locus of 254 A/G of ABCF1 gene, there were significantly associated with the back fat thickness, left and right nipple of teat number in American Large White pigs(P<0.05), and the birth weight in France Large White pigs(P<0.05). These results suggest that FRZB and ABCF1 may be the major candidate genes for growth traits in pigs. |
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| Keywords: | FRZB ABCF1 Polymorphism Growth traits Association analysis Pig |
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