| 麦冬水提物对猫肾细胞的影响研究 |
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| 引用本文： | 陈融,陈凯,张赛奇,刘博,王米,张可煜,郭利伟.麦冬水提物对猫肾细胞的影响研究[J].中国动物传染病学报,2022(1). |
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| 作者姓名： | 陈融 陈凯 张赛奇 刘博 王米 张可煜 郭利伟 |
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| 作者单位： | 长江大学;中国农业科学院上海兽医研究所农业农村部兽用化学药物及制剂学重点实验室;上海比瑞吉宠物用品股份有限公司 |
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| 基金项目： | 有益草本对宠物安全性和饲养应用研究(20190001-08)。 |
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| 摘 要： | 麦冬是我国传统中药之一,兼备保健和治疗作用。为了探究麦冬能否应用在宠物食品中,本试验以不同浓度的麦冬水提物(3.91~8000μg/mL)为受试药物,从细胞的形态、增殖、凋亡及周期4个方面对猫肾细胞(F81)进行安全性评价。结果表明:在试验浓度范围内,麦冬水提物没有抑制F81的增殖,且在3.91~62.5μg/mL的浓度范围内,凋亡及周期结果经统计学分析均无显著性差异,与对照组接近,且细胞形态良好。说明在一定浓度范围内,麦冬水提物对F81细胞无毒害作用。
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| 关 键 词： | 麦冬水提物 猫肾细胞 细胞增殖 细胞周期 细胞凋亡 |
Effects of Aqueous Extract of Ophiopogon Japonicus on Cat Kidney Cells |
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| CHEN Rong,CHEN Kai,ZHANG Saiqi,LIU Bo,WANG Mi,ZHANG Keyu,GUO Liwei.Effects of Aqueous Extract of Ophiopogon Japonicus on Cat Kidney Cells[J].Chinese Journal of Animal Infectious Diseases,2022(1). |
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| Authors: | CHEN Rong CHEN Kai ZHANG Saiqi LIU Bo WANG Mi ZHANG Keyu GUO Liwei |
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| Institution: | (Yangtze University,Jinzhou 434023,China;Key Laboratory of Veterinary Chemical Drugs and Pharmaceutics,Ministry of Agriculture and Rural Affairs,Shanghai Veterinary Research Institute,CAAS,Shanghai 200241,China;R&D Center of Shanghai Bridge Pet Care Co.,Ltd.,Jinshan District of Shanghai 201506,China) |
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| Abstract: | Ophiopogon japonicus is one of the traditional Chinese medicines in China,which has both health care and therapeutic effects.In order to verify the feasibility of Ophiopogon japonicus in pet foods,different concentrations(3.91~8000μg/mL)of water extracts were inoculated onto cat kidney cells(F81)to evaluate its toxicity through cell morphology,proliferation,apoptosis and cycles.The results showed that the water extract of Ophiopogon japonicus did not inhibit the proliferation of F81 at the tested concentrations.There was no signifi cant difference in apoptosis,morphology and cycle at the concentration of 3.91~62.5μg/mL.In conclusion,the water extract of Ophiopogon japonicus had no toxic effect on F81 cells in a certain concentration range. |
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| Keywords: | Ophiopogon japonicus water extract cat kidney cell cell proliferation cell apoptosis cell cycles toxicity |
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