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禽流感油乳剂灭活疫苗的研制
引用本文:罗开健,辛朝安.禽流感油乳剂灭活疫苗的研制[J].中国兽医杂志,2001,37(4):6-9.
作者姓名:罗开健  辛朝安
作者单位:华南农业大学动物医学系,
基金项目:广东省“九五攻关”资助项目(粤科计[1995]82号)
摘    要:以禽流感病毒(AIV)H5N4株,H7N3株为抗原,分别研制了H5N4、H7N3油乳剂灭活疫苗,并对其物理性状、安全性、免疫效力、保存期及抗体消长规律进行了检测。结果表明,3种抗原含量不同的H5N4疫苗在免疫后3周-9个月对AIV-H5N4攻击均获8/8保护,H7N3疫苗在免疫后3周与3个月时对AIV-H5N4攻击则分别保护6/8与3/7,疫苗4℃保存15个月,其免疫效力没有下降。

关 键 词:禽流感病毒  AIV-H5N4  AIV-H7N3  油乳剂灭活疫苗
文章编号:0529-6005(2001)04-0006-04
修稿时间:1999年12月13

Development of inactivated oil emulsion vaccines for avian influenza (AIV H 5N 4 and AIV H 7N 3)
LUO Kai-jian,XIN Chao-an.Development of inactivated oil emulsion vaccines for avian influenza (AIV H 5N 4 and AIV H 7N 3)[J].Chinese Journal of Veterinary Medicine,2001,37(4):6-9.
Authors:LUO Kai-jian  XIN Chao-an
Abstract:A monovalent inactivated oil-emulsion vaccines were developed from avian influenza viruses of H5N4 and H7N3 respectively.The physical characteristics, security, efficacy,stability and immune response of the vaccines were further studied.Results showed that all chickens vaccinated with the vaccines of H5N4 were protected when challenged with AIV-H5N4 from 3 weeks to 9 months postvaccination, and 6 out of 8 and 3 out of 7 chickens vaccinated with the vaccine of H7N3 were protected when challenged with AIV-H5N4.The vaccines were still safe and effective when stored for 15 months at 4℃.
Keywords:avian influenza  AIV  H_5N_4  AIV  H_7N_3  inactivated oil  emulsion vaccine
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