| 柔嫩艾美耳球虫地克珠利抗药株的实验室诱导 |
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| 引用本文： | 王慧珍,沈祥广,刘雅红.柔嫩艾美耳球虫地克珠利抗药株的实验室诱导[J].中国兽医寄生虫病,2009,17(3):62-65. |
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| 作者姓名： | 王慧珍 沈祥广 刘雅红 |
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| 作者单位： | 1. 青岛康地恩药业有限公司,青岛,266061;华南农业大学,广州,510642
2. 华南农业大学,广州,510642 |
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| 摘 要： | 采用药物浓度递增法，以0．07mg／L地克珠利为起始诱导浓度连续传代，以最适抗球虫指数（POAA）、病变记分减少率（RLS）和相对卵囊产量（ROP）3项指标综合判定抗药性。经12次传代，该诱导虫株对1．5mg／L地克珠利具有完全抵抗力。试验结果表明，用实验室方法诱导柔嫩艾美耳球虫抗药株完全可行。
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| 关 键 词： | 柔嫩艾美耳球虫 地克珠利 抗药性 鸡 |
EXPERIMENTAL INDUCTION OF DICLAZURIL- RESISTANT STRAINS OF EIMERIA TENELLA |
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| WANG Hui-zhen,SHEN Xiang-guang,LIU Ya-hong.EXPERIMENTAL INDUCTION OF DICLAZURIL- RESISTANT STRAINS OF EIMERIA TENELLA[J].Chinese Journal of Veterinary Parasitology,2009,17(3):62-65. |
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| Authors: | WANG Hui-zhen SHEN Xiang-guang LIU Ya-hong |
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| Institution: | WANG Hui-zhen, SHEN Xiang-guang, LIU Ya-hong (1. Qingdao Continent Pharmaceutical, Qingdao 266061 , China; 2. College of Veterinary Medicine, South China Agricultural University, Gangzhou 510642, China) |
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| Abstract: | The resistance of Eimeria tenella strain to anticoccidial drug diclazuril was induced in the laboratory. The initial concentration of diclazuril was 0. 07 mg/L. Eimeria tenella was serially passaged in chickens with gradually increasing concentrations of diclazuril. Based on percent of optimum anticoccidial activity, reduction of lesion scores and relative oocyst production, a diclazuril resistant E. tenella strain was selected. After 12 passages in chickens, the strain was resistant to 1.5 mg/L diclazuril. Results suggest that it is feasible to induce anticoccidiaI drug resistant E. tenella strains under experimental condition. |
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| Keywords: | E tenella Diclazuril drug-resistence chicken |
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