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柔嫩艾美耳球虫地克珠利抗药株的实验室诱导
引用本文:王慧珍,沈祥广,刘雅红. 柔嫩艾美耳球虫地克珠利抗药株的实验室诱导[J]. 中国兽医寄生虫病, 2009, 17(3): 62-65
作者姓名:王慧珍  沈祥广  刘雅红
作者单位:1. 青岛康地恩药业有限公司,青岛,266061;华南农业大学,广州,510642
2. 华南农业大学,广州,510642
摘    要:采用药物浓度递增法,以0.07mg/L地克珠利为起始诱导浓度连续传代,以最适抗球虫指数(POAA)、病变记分减少率(RLS)和相对卵囊产量(ROP)3项指标综合判定抗药性。经12次传代,该诱导虫株对1.5mg/L地克珠利具有完全抵抗力。试验结果表明,用实验室方法诱导柔嫩艾美耳球虫抗药株完全可行。

关 键 词:柔嫩艾美耳球虫  地克珠利  抗药性  

EXPERIMENTAL INDUCTION OF DICLAZURIL- RESISTANT STRAINS OF EIMERIA TENELLA
WANG Hui-zhen,SHEN Xiang-guang,LIU Ya-hong. EXPERIMENTAL INDUCTION OF DICLAZURIL- RESISTANT STRAINS OF EIMERIA TENELLA[J]. Chinese Journal of Veterinary Parasitology, 2009, 17(3): 62-65
Authors:WANG Hui-zhen  SHEN Xiang-guang  LIU Ya-hong
Affiliation:WANG Hui-zhen, SHEN Xiang-guang, LIU Ya-hong (1. Qingdao Continent Pharmaceutical, Qingdao 266061 , China; 2. College of Veterinary Medicine, South China Agricultural University, Gangzhou 510642, China)
Abstract:The resistance of Eimeria tenella strain to anticoccidial drug diclazuril was induced in the laboratory. The initial concentration of diclazuril was 0. 07 mg/L. Eimeria tenella was serially passaged in chickens with gradually increasing concentrations of diclazuril. Based on percent of optimum anticoccidial activity, reduction of lesion scores and relative oocyst production, a diclazuril resistant E. tenella strain was selected. After 12 passages in chickens, the strain was resistant to 1.5 mg/L diclazuril. Results suggest that it is feasible to induce anticoccidiaI drug resistant E. tenella strains under experimental condition.
Keywords:E. tenella  Diclazuril  drug-resistence  chicken
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