饲用葡萄糖三丁酸酯的设计与合成

以D-无水葡萄糖为原料,通过苯甲醛保护、酯化反应、脱去苯甲醛保护3步反应,制备葡萄糖三丁酸酯。结果表明,最佳条件反应条件为:以DMF为溶剂,DMAP为催化剂,在常温下与丁酸反应,化合物2的产率最高,为90.5%,所得中间产物及目标产物的化学结构均经核磁共振氢谱(~1H-NMR)和核磁共振碳谱(¹³C-NMR)确定。该反应具有催化剂廉价易得、反应条件温和、操作简单等优点,适合大量生产。

Design and Synthesis of Feed-use Glucose Tributyrate

In this study, the feed-use glucose tributyrate was synthesized using anhydrous dextrose as raw material through three reaction steps of benzaldehyde protection, esterification and removal of benzaldehyde protection. The optimized synthesis condition was as follows: DMF and DMAP was used as solvent and catalyst, respectively;the highest yield of compounds 2 (90.5%) was obtained when reacted with butyrate under room temperature;the chemical structure of the obtained intermediate and target products was identified by using 1H-NMR and 13C-NMR. The reaction steps designed in this study has the advantages of cheap and easy to get catalyst, mild reaction conditions, easy operation and suitability for mass production.