伪狂犬病毒囊膜糖蛋白gC的研究进展

伪狂犬病毒（pseudorabies virus,PRV）感染能够引起猪的大面积死亡,给养猪业造成巨大损失,减毒活疫苗和灭活疫苗被广泛使用于猪的伪狂犬病防治。PRV的囊膜糖蛋白gC基因（gC）是病毒增殖所非必需的基因,但是缺失gC基因的PRV不能有效地黏附靶细胞表面。通过综述PRV的囊膜糖蛋白gC的结构和功能,以及gC蛋白在疫苗研制中的应用,为伪狂犬病的防控提供依据。

Research Advances in Envelope Glycoprotein gC of Pseudorabies Virus

Pseudorabies virus （PRV） infection can cause large-scale death in pigs and bring huge economic losses to the pig industry. The live attenuated vaccines and inactivated vaccines are widely used in prevention of pseudorabies in pigs. While the gene of envelope glycoprotein gC of PRV is a non-essential gene for viral proliferation, the PRV lacking of the gC gene cannot effectively adhere to the surface of the target cell. The structure and function of the envelope glycoprotein gC of PRV and its application in vaccine development were reviewed, in hoping to provide basis for the prevention and control of pseudorabies.