Transportation stress alters the expression of immunoregulatory cytokines in the porcine thymus |
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| Authors: | Qiongxia Lv Shuxia Zhang Ruqian Zhao |
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| Institution: | 1. Institut Halieutique et des Sciences Marines, University of Toliara, Madagascar;2. Mer Molécules Santé – EA 2160, University of Nantes, 44000 Nantes, France;3. ThalassOMICS, Plateforme CORSAIRE- Biogenouest, 44000 Nantes, France;4. Laboratoire d’Etude des Résidus et Contaminants dans les Aliments (LABERCA), Oniris, 44000 Nantes, France;5. Chimie et Interdisciplinarité: Synthèse Analyse Modélisation (CEISAM), UMR 6230 – CNRS, University of Nantes, 44000 Nantes, France;6. Institut de Systématique, Évolution, Biodiversité, ISYEB – UMR 7205 - CNRS, MNHN, UPMC, EPHE, Muséum national d’histoire naturelle, Sorbonne Universités, 57 rue Cuvier, CP39, 75231 Paris Cedex 5, France |
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| Abstract: | This study investigated the effects of transportation stress on blood concentrations of the main pro-inflammatory cytokines (interleukins IL-1β, IL-2 and IL-6; tumour necrosis factor-α) and anti-inflammatory cytokines (IL-4 and IL-10) and the expression of these cytokines and their receptors in the thymus. Pigs were assessed after 1, 2 and 4 h of transportation (n = 5 per group), with normal housing conditions as a control (n = 4). Serum concentrations of IL-2, IL-6 and IL-10 were highest at 1 h, whereas concentrations of IL-6 and IL-10 were significantly decreased at 4 h. Expression of these three cytokines and their receptors was also significantly altered in the thymus during transportation stress. Serum IL-10 concentrations and thymus IL-10 mRNA expression were significantly correlated. The thymus may contribute towards the regulation of cytokines in pigs during transportation. |
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