Decrease in bovine CD14 positive cells in colostrum is associated with the incidence of mastitis after calving |
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| Authors: | Yoshio Kiku Tomomi Ozawa Shiro Kushibiki Madoka Sudo Kouhei Kitazaki Noriaki Abe Hideyuki Takahashi Tomohito Hayashi |
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| Institution: | (1) National Institute of Animal Health, 3-1-5 Kan-nondai, Tsukuba Ibaraki, 305-0856, Japan;(2) National Institute of Livestock and Grassland Science, 2 Ikenodai, Tsukuba Ibaraki, 305-0901, Japan;(3) Fukuoka Agricultural Research Center, 587 Yoshigi, Ooaza, Chikushino Fukuoka, 818-8549, Japan;(4) Iwate Prefecture Northern Regional Livestock Hygiene Service Center, 23-9-1, Sannai, Karumai Iwate, 028-6222, Japan; |
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| Abstract: | During the postpartum period there is a high incidence of mastitis in dairy cows. The reason for this increased risk of mastitis
still remains unclear. Since leukocytes in colostrum have an important role in preventing the onset of mastitis, we investigated
the leukocyte populations, which express CD4, CD8, CD14, CD21 or WC1, in colostrum as well as in blood obtained from 14 Holstein
cows. Eight cows developed mastitis within a week after calving and the other 6 remained healthy. The percentage of CD14+
cells in colostrum was significantly lower in mastitic cows than in healthy cows. There were no significant differences in
other marker positive cells either in the colostrum or in the blood. The CD14+ cells in colostrum play an important role of
defense against invading microorganisms in the mammary glands. Our results suggested that the lower percentage of CD14+ cells
in colostrum might predict the incidence of mastitis in the following period. |
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