不同剂量25羟基维生素D3对断奶前犊牛血液生化指标、抗氧化能力和免疫功能的影响

为研究不同剂量25羟基维生素D₃25(OH)VD₃]对断奶前犊牛血液水平、抗氧化能力和免疫功能的影响,选取18 头健康状况良好的新生荷斯坦犊牛,随机分成3 组,每组6 头进行为期56 天的饲养试验。分为对照组不添加25(OH)VD₃]、低剂量组25(OH)VD₃添加量6 000 IU/头·天]和高剂量组25(OH)VD₃添加量12 000 IU/头·天]。结果表明,与对照组相比,随着25(OH)VD₃添加剂量增加,血浆生长激素、胰岛素样生长因子-1、过氧化氢酶、超氧化物歧化酶、总抗氧化能力以及免疫球蛋白G(IgG)含量显著增加(P<0.05),而丙二醛含量随剂量增加而存在降低趋势(P=0.079)。与对照组和低剂量组相比,高剂量组血浆免疫球蛋白A(IgA)含量有增加趋势(P=0.059)。综上所述,断奶前犊牛饲喂高剂量25(OH)VD₃有利于促进体内生长激素和胰岛素样生长因子-1分泌,可提高犊牛抗氧化能力,增强免疫功能。

Effects of Different Doses of 25-hydroxyvitamin D3 on Blood Biochemical Indices,Antioxidant Capacity and Immune Function of Pre-weaning Calves

To study the effects of 25-hydroxyvitamin D₃ 25(OH)VD₃] at different doses on blood level, antioxidant capacity and immune function of pre-weaning calves,18 healthy Holstein calves were randomly assigned to 3 groups with 6 calves in each group for 56 days. They were divided into control group 0 IU 25(OH)VD₃ per calf per day], low-dose group 6 000 IU 25(OH)VD₃ per calf per day] and high-dose group 12 000 IU 25(OH)VD₃ per calf per day]. The results showed that compared with the control group, the contents of plasma growth hormone, insulin-like growth factor-1, catalase, superoxide dismutase,total antioxidant capacity and immunoglobulin G (IgG) were significantly increased (P<0.05) with the increasing dose of 25(OH)VD₃. The content of malondialdehyde decreased with the dosage of 25(OH)VD₃ increased (P=0.079). Compared with the control group and the low-dose group, the plasma immunoglobulin A (IgA) content in the high-dose group had an increasing trend (P=0.059). In conclusion,feeding high doses of 25(OH)VD₃ to calves before weaning can promote the secretion of growth hormone and insulin-like growth factor-1,improve antioxidant capacity, and enhance immune function.