Immunohistochemical analysis of cyclooxygenase-2 induction during wound healing in dog skin |
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| Authors: | T Hamamoto A Yabuki O Yamato M Fujiki K Misumi M Matsumoto |
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| Institution: | aLaboratory of Veterinary Anatomy, Department of Veterinary Medicine, Kagoshima University, Japan;bLaboratory of Veterinary Clinical Pathology, Department of Veterinary Medicine, Kagoshima University, Korimoto 1-21-24, Kagoshima, Japan;cLaboratory of Veterinary Surgery, Department of Veterinary Medicine, Kagoshima University, Japan |
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| Abstract: | Cyclooxygenase (COX)-2 is an inducible isoform of COX and is expressed under abnormal health conditions. This study elucidated the cutaneous induction of COX-2 during the wound healing processes in dog skin. Dog skin was sutured after punch biopsy and investigated histologically and immunohistochemically on days 0 (normal), 1, 3, 5, 7, 10, and 14 after injury. Histological changes, including infiltration of inflammatory cells and proliferation of fibroblast-like cells, were observed as predicted, and there was a close and significant correlation between these 2 events. COX-2-positive cells were detected in the epidermis between days 1 and 7, and bimodal peaks were observed in the case of the percentage of COX-2-positive cells. In inflammatory cells, COX-positive signals were detected on day 3 only. Here, we clarified the localization and pattern of the induced COX-2 expression during wound healing in dog skin. |
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| Keywords: | Cyclooxygenase-2 Dog Epidermis Immunohistochemistry Skin Wound healing |
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