| 双顺反子表达质粒在DNA疫苗研究中的应用 |
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| 引用本文： | 张淼涛,白华,童德文.双顺反子表达质粒在DNA疫苗研究中的应用[J].中国兽医科技,2006,36(5):424-428. |
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| 作者姓名： | 张淼涛 白华 童德文 |
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| 作者单位： | [1]安庆师范学院生物系,安徽安庆246011 [2]西北农林科技大学动物科技学院,陕西杨凌712100 |
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| 基金项目： | 国家自然科学基金项目（30371067）;霍英东教育基金项目（91033） |
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| 摘 要： | 简述了DNA疫苗的研究概况，介绍了真核双表达质粒的结构特点及其在基因佐剂和二价DNA疫苗中的应用情况，总结分析了双表达质粒的优点和存在的问题，并对其今后在DNA疫苗中的研究方向和前景进行了展望。
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| 关 键 词： | 双顺反子表达质粒 DNA疫苗 基因重组 |
| 文章编号： | 1673-4696（2006）05-0424-05 |
| 收稿时间： | 2006-02-13 |
| 修稿时间： | 2006-05-10 |
Application of dicistronic expression plasmids to DNA vaccines |
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| ZHANG Miao-tao , BAI Hua , TONG De-wen.Application of dicistronic expression plasmids to DNA vaccines[J].Chinese Journal of Veterinary Science and Technology,2006,36(5):424-428. |
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| Authors: | ZHANG Miao-tao BAI Hua TONG De-wen |
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| Abstract: | DNA vaccine is a new type vaccine, which can induce cellular and humoral immune responses, and plays an important role in the prevention and control of diseases. In the present article, previous studies on DNA vaccines were briefly reviewed, and the structural characteristics of dicistronic expression plasmid and its application in studies of gene adjuvants and bivalent DNA vaccines were summarized. Advantages and problems of dicistronic expression plasmids were outlined and analyzed. Prospects and future research directions for dicistronic expression plasmids in the development of DNA vaccines were discussed. |
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| Keywords: | dicistronic expression plasmid DNA vaccine gene recombination |
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