| 脱氧雪腐镰刀菌烯醇对猪毒害作用及毒理机制研究进展 |
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| 引用本文： | 戴超辉,李辉,赵为民,付言峰,廖超,李碧侠,王学敏,程金花.脱氧雪腐镰刀菌烯醇对猪毒害作用及毒理机制研究进展[J].畜牧兽医学报,2023,54(1):24-35. |
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| 作者姓名： | 戴超辉 李辉 赵为民 付言峰 廖超 李碧侠 王学敏 程金花 |
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| 作者单位： | 江苏省农业科学院畜牧研究所, 农业农村部种养结合重点实验室, 江苏省农业种质资源保护与利用平台, 南京 210014 |
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| 基金项目： | 江苏省农业科技自主创新资金项目(CX(22)3197)；国家自然科学基金(32272883)，江苏省自然科学基金(BK20211140)；财政部和农业农村部：国家现代农业产业技术体系(CARS-PIG-35)；江苏省农业重大新品种创制项目(PZCZ201733) |
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| 摘 要： | 脱氧雪腐镰刀菌烯醇(deoxynivalenol, DON)是一种常见的污染粮食、饲料和食品的霉菌毒素，严重影响人和牲畜的健康。猪对DON非常敏感，DON可造成猪拒食、生长抑制、呕吐以及器官损伤、细胞毒性、免疫毒性等毒害作用。本文主要综述了DON对猪的毒害作用、毒理机制以及解毒剂开发等方面的研究进展，尤其关注DON毒理作用的遗传调控研究，旨在为从遗传本质提高猪对脱氧雪腐镰刀菌烯醇的抵抗力提供更全面的参考。
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| 关 键 词： | 猪 脱氧雪腐镰刀菌烯醇 毒害作用 毒理机制 解毒剂 遗传调控 |
| 收稿时间： | 2022-06-10 |
Research Progress in Toxic Effect of Deoxynivalenol on Pigs and Its Toxicological Mechanism |
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| DAI Chaohui,LI Hui,ZHAO Weimin,FU Yanfeng,LIAO Chao,LI Bixia,WANG Xuemin,CHENG Jinhua.Research Progress in Toxic Effect of Deoxynivalenol on Pigs and Its Toxicological Mechanism[J].Acta Veterinaria et Zootechnica Sinica,2023,54(1):24-35. |
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| Authors: | DAI Chaohui LI Hui ZHAO Weimin FU Yanfeng LIAO Chao LI Bixia WANG Xuemin CHENG Jinhua |
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| Institution: | Jiangsu Germplasm Resources Protection and Utilization Platform, Key Laboratory of Crop and Livestock Integration of Ministry of Agriculture and Rural Affairs, Institute of Animal Science, Jiangsu Academy of Agricultural Sciences, Nanjing 210014, China |
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| Abstract: | Deoxynivalenol (DON), is one of the common mycotoxins that contaminate grain, feed and food, which seriously affects the health of humans and livestock. Pigs are very sensitive to DON, which can cause toxic effects such as antifeeding, growth inhibition, vomiting, organ damage, cytotoxicity, and immunotoxicity to pigs. The toxic effects, toxicological mechanisms and antidote development of DON on pigs were reviewed in this paper. Specially, the genetic regulation of the toxicological effects of DON was concerned, which aimed to provide more comprehensive references for improving the resistance of pigs to deoxynivalenol from genetic nature. |
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| Keywords: | pig deoxynivalenol toxic effect toxicological mechanism antidote genetic regulation |
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