| 阿维菌素类药物的研究进展 |
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| 引用本文： | 扈洪波,朱蓓蕾,李俊锁.阿维菌素类药物的研究进展[J].畜牧兽医学报,2000,31(6):520-529. |
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| 作者姓名： | 扈洪波 朱蓓蕾 李俊锁 |
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| 作者单位： | 中国农业大学动物医学院,北京100094 |
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| 摘 要： | 阿维菌素类药物（Avermectins)是目前最为优良的一类广谱效兽用抗寄生虫药，在这类药物中已商品化的有阿维菌素、 维菌素、多拉菌素和Eprinomectin，本文就该类药物的理化特性，作用机制、药物动力学、制剂、药效学、尼性及毒理学等方面的研究进展进行了综述，并与同属大环内酯类驱动虫的Milbemycins进行了比较。
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| 关 键 词： | 阿维菌素类药物 作用机制 抗药性 毒理学 |
PROGRESS IN RESEARCH OF AVERMECTINS |
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| Hu Hongbo,Zhu Beilei,Li Junsuo.PROGRESS IN RESEARCH OF AVERMECTINS[J].Acta Veterinaria et Zootechnica Sinica,2000,31(6):520-529. |
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| Authors: | Hu Hongbo Zhu Beilei Li Junsuo |
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| Abstract: | Avermectins are a family of macrocylic lactone anthelmintics with a broad spectrum of activity against endo and ectoparasites.Avermectin B 1(abamectin),ivermectin,doramectin and eprinomectin have been used commercially in this class of drugs.The paper made a review of their chemistry,mode of action,pharmacokinetics,preparations,spectrum of activity,resistance,toxicology,and compared with milbemycins that also belong to macrocylic lactone anthelmintics. |
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| Keywords: | Avermectins Chemistry Mode of action Pharmacokinetics Preparations Spectrum of activity Resistance Toxicology |
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