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鸡马立克氏病Z4+Fc126双价活疫苗配比试验
引用本文:吴长新,张如宽.鸡马立克氏病Z4+Fc126双价活疫苗配比试验[J].畜牧兽医学报,1994,25(3):279-283.
作者姓名:吴长新  张如宽
作者单位:江苏农学院畜禽传染病实验室
摘    要:本研究用不同剂量的Z4和Fc126配制成鸡马立克氏病双价活疫苗做配比试验。2个试验8种配比的Z4和Fc126双介活疫苗免疫易感鸡,攻毒保护试验结果表明,Z4无论与Fc126细胞结合毒还是与Fc126冻干毒配成双价活疫苗,均能给免疫鸡群提供坚强的免疫保护力,Z4与Fc126间存在很强的免疫协同作用,即使Z4剂量小至仅占疫苗病毒PFU总数的10%,这种协同作用仍能使免疫鸡群产生较强的免疫保护力。

关 键 词:双价活疫苗  鸡病  马立克氏病

COMPARATIVE EFFICACY TRIALS OF DIFFERENT DOSE PROPOBTIONS OF COMPOSITE VIRUSES IN THE MD BIVALENT VACCINE Z_4+F_(c126)
Wu Changxin, Zhang Rukuan, Liu Xiufan.COMPARATIVE EFFICACY TRIALS OF DIFFERENT DOSE PROPOBTIONS OF COMPOSITE VIRUSES IN THE MD BIVALENT VACCINE Z_4+F_(c126)[J].Acta Veterinaria et Zootechnica Sinica,1994,25(3):279-283.
Authors:Wu Changxin  Zhang Rukuan  Liu Xiufan
Abstract:In order to decide the proper dose proportion of composite virus in the MD bivalentwaccine Z_4+F_(c126), two trials were carried out. One trial was that the proptectiveefficacies of the bivalent vaccines which contained 500PFUs of Z_4 plus 1000, 2000 or3000 PFUs of cell-free Fc126 or plus 1000 PFUs of cell-associated Fc126 virus wereevaluated in commercial Isabrown chickens against BJ-1 strain challenge. Protectiveefficacies among the four bivalent vaccines did not differ significantly. There were noobvious differences between bivalent vaccines containing Z_4 and Fc126 or SB1 and F_(c126)with respect to their protective potencies. The result of another trial evaluated incommiercial Isabrown chickens against GA strain challenge showed that the Proportiveefficacies of the bivalent vaccines 50PFUs of Z_4 Plus 500PFUs of F_(c126), 200PFUs ofZ_4 plus 1000PFUs of Fc126, 500PFUs of Z_4 plus 1000PFUs of F_(c126) and 500PFUs ofZ_4 plus 5000PFUs of F_(cl26) did not differ significantly. All those eight proportionalbivalent vaccines in the two trials could give the chickens effective potency againstMD. But the three monovalent vaccines including Z_4, cell-free F_(cl26) and cell-associatedF_(c126) could not give the chickens effective potency to MD comparing with the bivalentvaccines containing Z_4 and F_(c126).
Keywords:Marek's disease  Bivalent vaccine  Protective efficacy  Comparativeefficacy trial  
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