环丙沙星对实验性猪支原体性肺炎的药效学研究

测定环丙沙星及对照药物对猪肺炎支原体的最小抑菌浓度，其中环丙沙星的抗支原体活性最强，最小抑菌浓度为0．01μg/ml。通过给18头健康猪气管内接种含有猪肺炎支原体的病肺悬液，复制具有典型症状的猪支原体性肺炎疾病模型，并进行环丙沙星2．5、5．0mg/kg肌注给药对实验性猪支原体性肺炎的疗效实验及血浆药物浓度监测，两组治愈率分别为83．3％（5／6）和100％（6／6）。治疗组多剂量给药期间，第1、3、5、7、9次给药后0．5及6h的血浆药物浓度，在2．5mg/kg剂量组平均为0．41μg/ml和0．17μg/ml,5.0mg/kg剂量组平均为0．71μg/ml和0．28μg/ml。两剂量组环丙沙星均无蓄积作用。

PHARMACODYNAMIC STUDY OF CIPROFLOXACIN AGAINST EXPERIMENTALLY INDUCED MYCOPLASMAL PNEUMONIA IN SWINE

The studies dealed with efficacy evaluation and monitored plasma drug concentration of ciprofloxaxin in pigs experimentally infected with Mycoplasma hyopneumoniae． In Vitro inhibitory tests showed that the MIC of ciprofloxacin against M．hyopneumoniae was 0．01 μg／ml． Pigs were experimentally induced mycoplasmal pneumonia and were treated by administration intramuscularly at the dose of 2．5 and 5．0 mg／kg of ciprofloxacin． The curative rates of two treated groups were 83．3％ and 100％，respectively． The plasma concentrations were monitored 0．5 h and 6．0 h after the lst， 3rd， 5 th， 7th， 9th administration．The results showed that the mean plasma concentrations of ciprofloxacin 0．5 h and 6．0 h after administration were 0．41 μg／ml and 0．17 μg／ml in the low-dose group， 0．71 μg／ml and 0．28 μg／ml in the high-dose group，respectively．In addtion，after multiple doses，there was not significantly plasma accumulation of ciprofloxacin．