| 番鸭呼肠孤病毒病活疫苗诱导的免疫应答分析 |
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| 引用本文： | 林锋强,陈仕龙,陈少莺,朱小丽,程晓霞,胡奇林,王劭.番鸭呼肠孤病毒病活疫苗诱导的免疫应答分析[J].畜牧兽医学报,2011,42(12). |
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| 作者姓名： | 林锋强 陈仕龙 陈少莺 朱小丽 程晓霞 胡奇林 王劭 |
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| 作者单位： | 福建省农业科学院畜牧兽医研究所,福州350013;福建省畜禽疫病防治工程技术研究中心,福州350013 |
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| 基金项目： | 福建省畜牧重大专项(2006NZ003-2) |
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| 摘 要： | 本研究旨在评价番鸭呼肠孤病毒病活疫苗对番鸭免疫功能的影响,探讨番鸭呼肠孤病毒病活疫苗的免疫机理；1日龄番鸭免疫番鸭呼肠孤病毒病活疫苗,分别于免疫后7～35 d观察番鸭生长发育,检测免疫番鸭血清中和抗体效价,外周血淋巴细胞、胸腺细胞和法氏囊细胞对ConA、LPS的反应,细胞毒T细胞(CTL)的细胞毒性作用.结果显示:免疫番鸭生长发育正常,免疫器官中胸腺明显增大；免疫后35 d血清中和抗体才开始上升；外周血和胸腺淋巴细胞对ConA的增殖反应显著提高(P＜0.05)；而外周血和法氏囊淋巴细胞对LPS增殖反应无显著变化(P＜0.05)；外周血细胞毒性T细胞杀伤功能增强(P＜0.05).结果提示番鸭呼肠孤病毒病活疫苗免疫后主要刺激提高番鸭细胞免疫功能,提高机体抵抗番鸭呼肠孤病毒的能力.
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| 关 键 词： | 番鸭呼肠孤病毒病活疫苗 番鸭 免疫应答 细胞免疫 |
The Study on Immunne Response of Muscovy Duck Reovirusis Alive Vaccine |
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| LIN Feng-qiang
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CHEN Shi-long
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CHEN Shao-ying
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ZHU Xiao-li
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CHENG Xiao-xia
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HU Qi-lin
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WANG Shao.The Study on Immunne Response of Muscovy Duck Reovirusis Alive Vaccine[J].Acta Veterinaria et Zootechnica Sinica,2011,42(12). |
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| Authors: | LIN Feng-qiang CHEN Shi-long CHEN Shao-ying ZHU Xiao-li CHENG Xiao-xia HU Qi-lin WANG Shao |
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| Institution: | LIN Feng-qiang1,2,CHEN Shi-long1,CHEN Shao-ying1,ZHU Xiao-li1,CHENG Xiao-xia1,HU Qi-lin1,WANG Shao1,2 (1.Institute of Animal Husbandry and Veterinary Medicine,Fujian Academy of Agriculture Sciences,Fuzhou 350013,China,2.Fujian Animal Diseases Control Technology Development Center,China) |
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| Abstract: | The experiment was conducted to access the effect of muscovy duck reovirusis alive vaccine on immune response and to explore the immune mechanism.After 1-day-old muscovy ducks were immunized,the growth and development were observed,neutralization antibody in the sera,proliferation responses of the lymphocytes in the peripheral blood,thymus and bursa cells to ConA and LPS,Cytotoxic activity of cytotoxic T lymphocytes(CTL) were detected.The results showed that the growth and development of the immunized musco... |
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| Keywords: | muscovy duck reovirusis alive vaccine immunological response cellular immunity |
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