| 肺动脉高压肉鸡肺小动脉中膜5-HT量及其与肺血管重构的关系 |
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| 引用本文： | 李英,曾健滢,韩前彪,唐兆新,李玉谷,宁章勇,潘家强.肺动脉高压肉鸡肺小动脉中膜5-HT量及其与肺血管重构的关系[J].畜牧兽医学报,2011,42(8). |
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| 作者姓名： | 李英 曾健滢 韩前彪 唐兆新 李玉谷 宁章勇 潘家强 |
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| 作者单位： | 华南农业大学兽医学院,广州,510642 |
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| 基金项目： | 国家自然科学基金(30600440) |
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| 摘 要： | 静脉注射纤维素粒子复制肉鸡肺动脉高压模型,观察肺小动脉中膜5-羟色胺(5-HT)表达和肺小动脉管壁病理形态学变化,探讨5-HT与肺血管重构的关系。80羽科宝肉鸡分为对照组(n=30)和试验组(n=50)。20日龄时,试验组每羽鸡静脉注射0.3 mL的纤维素悬液;对照组每羽鸡静脉注射等体积生理盐水。记录肺动脉高压综合征(PHS)发病率,并分别于21、28、35、42 d从各组随机抽样,测定右心室/全心室质量比(RV/TV)、红细胞压积(PCV)、血红蛋白(Hb)、肺小动脉管壁面积/管总面积(WA/TA)、平均中膜厚度(mMTPA)和肺厚壁末梢血管百分比(TWPV%);采用免疫组化方法标记5-HT,并用病理图像分析软件检测肺小动脉5-HT的量。结果表明:试验组肉鸡PHS发病率显著高于对照组(P<0.05);RV/TV值在35、42 d时显著升高(P<0.05);PCV在28、35 d时显著升高(P<0.05);Hb值在35 d时显著升高(P<0.05);血管mMTPA、WA/TA和TWPV%在35、42 d时均显著升高(P<0.05);肺小动脉5-HT含量升高,在各时间点均差异显著(P<0.05),且5-HT含量...
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| 关 键 词： | 肺动脉高压 5-羟色胺 肺血管重构 纤维素微粒 肉鸡 |
5-HT Content in Pulmonary Arteriola Media of Broiler with Pulmonary Hypertension and Its Relationship with Pulmonary Vascular Remodeling |
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| LI Ying,ZENG Jian-ying,HAN Qian-biao,TANG Zhao-xin,LI Yu-gu,NING Zhang-yong,PAN Jia-qiang.5-HT Content in Pulmonary Arteriola Media of Broiler with Pulmonary Hypertension and Its Relationship with Pulmonary Vascular Remodeling[J].Acta Veterinaria et Zootechnica Sinica,2011,42(8). |
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| Authors: | LI Ying ZENG Jian-ying HAN Qian-biao TANG Zhao-xin LI Yu-gu NING Zhang-yong PAN Jia-qiang |
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| Institution: | LI Ying,ZENG Jian-ying,HAN Qian-biao,TANG Zhao-xin,LI Yu-gu,NING Zhang-yong,PAN Jia-qiang (College of Veterinary Medicine,South China Agricultural University,Guangzhou 510642,China) |
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| Abstract: | The present study was conducted to examine the 5-hydroxytrytamine(5-HT) content in pulmonary arterioles and the morphological changes of pulmonary arterioles of broiler with pulmonary hypertension induced by intravenous injection of cellulose particles,with the purpose to explore the relationship between 5-HT level and pulmonary vascular remodeling.Eighty broilers were randomized into control group(n=30) and test group(n=50).In the test group,each chicken was intravenously injected with 0.3 mL cellulose sus... |
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| Keywords: | pulmonary hypertension 5-HT Pulmonary vascular remodeling cellulose particles Broiler |
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