Adrenocortical responses to tumor necrosis factor-alpha and interferon-gamma in cattle |
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| Authors: | Soliman Mohamed Okamoto Shiki Kitamura Hiroshi Kushibiki Shiro Kimura Kazuhiro Saito Masayuki |
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| Institution: | Laboratory of Biochemistry, Department of Biomedical Sciences, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo 060-0818, Japan. ahmed276@vetmed.hokudai.ac.jp |
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| Abstract: | The responses of plasma cortisol and adrenocorticotropic hormone (ACTH) were examined to intravenous injection of recombinant bovine tumor necrosis factor-alpha (TNF-alpha) and interferon-gamma (INF-gamma) in Holstein cows. INF-gamma induced dose-dependent rises in the plasma levels of both cortisol and ACTH, while TNF-alpha induced comparable plasma cortisol responses with much smaller rises in plasma ACTH. The results suggest a direct stimulatory action of TNF-alpha on cortisol secretion from the adrenal gland in cattle. |
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