Iron Status in Blood Donor Dogs |
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Authors: | S Zaldívar‐López MC Iazbik LM Marín CG Couto |
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Institution: | 1.Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Columbus, OH;2.Veterinary Medical Center, The Ohio State University, Columbus, OH;3.Comprehensive Cancer Center, The Ohio State University, Columbus, OH;4.The Research Institute at Nationwide Children''s Hospital, Columbus, OH;5.Present address: Grupo de Genómica y Mejora Animal, Departmento de Genética, Facultad de Veterinaria, Universidad de Córdoba, Córdoba, Spain |
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Abstract: | BackgroundDespite the popularity of canine blood donor (BD) programs, there is scarce scientific information regarding iron status in this canine population of dogs.ObjectiveTo assess iron status in dogs used in a blood donor program.AnimalsA total of 130 healthy dogs (75 BD, 55 controls C]) were included. A subset of dogs (n = 12) were used to evaluate the effects of repetitive donations by having a second and more recent sample analyzed.MethodsSerum iron concentration (SI), unsaturated iron‐binding capacity (UIBC), total iron‐binding capacity (TIBC), and percentage transferrin saturation (%SAT) were obtained. Values were compared using a 2‐way ANOVA (factors: BD status, breed). For the subset of BD, the first sample (less frequent donors ‐LD‐, after a mean of 3.8 donations) was compared to a second sample (experienced donors ‐ED‐, mean 13.6 donations) using a paired t‐test.Results
SI (183.7 ± 55.3 μg/dL) and %SAT (55.7 ± 17.4%) were higher and UIBC (152.6 ± 73.3 μg/dL) was lower in BD dogs than in C (153.9 ± 51.7 μg/dL, 43.8 ± 17.8%, and 224.1 ± 120.6 μg/dL, respectively). Also, UIBC and TIBC were lower, and %SAT higher in Greyhounds when compared with non‐Greyhounds. ED had decreased %SAT and increased UIBC and TIBC when compared with LD.Conclusions and Clinical ImportanceOur canine BD population did not have iron deficiency and had higher SI concentration than C. However, ED (~14 consecutive blood donations every ~8 weeks) developed a mild iron deficiency, although values were still within canine reference intervals. Greyhounds have higher %SAT than non‐Greyhounds, which might be a breed‐specific peculiarity. |
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Keywords: | Greyhound Iron deficiency Iron‐ binding capacity Transferrin saturation |
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