Phase II Clinical Trial of Carboplatin in Canine Transitional Cell Carcinoma of the Urinary Bladder |
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| Authors: | Ruthanne Chun Deborah W Knapp William R Widmer Dennis B DelNicola Nita W Glickman Thomas Kuczek Amalia Degortari Connie M Han |
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| Institution: | Department of Veterinary Clinical Sciences College of Veterinary Medicine, Purdue University, West Lafayette, IN;Department of Veterinary Pathobiology College of Veterinary Medicine, Purdue University, West Lafayette, IN;Center for Applied Ethology and Human-Animal Interaction College of Veterinary Medicine, Purdue University, West Lafayette, IN;Department of Statistics College of Veterinary Medicine, Purdue University, West Lafayette, IN |
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| Abstract: | Fourteen dogs with histologically-confirmed transitional cell carcinoma (TCC) of the urinary bladder were treated with 300 mg/m2 carboplatin every 3 weeks. Response to therapy was assessed with abdominal radiography, double contrast cystography, urinary bladder ultrasonography and thoracic radiography before therapy and at 6–week intervals during therapy. Dogs were monitored for hematologic toxicity with a CBC and platelet count performed immediately before and 10 to 14 days after carboplatin treatment. Tumor responses included progressive disease in 11 dogs and stable disease in 1 dog. Two dogs were euthanized due to carboplatin toxicity before assessment of tumor response. Toxicity included thrombocytopenia with or without neutropenia in 7 dogs and gastrointestinal toxicity in 6 dogs. Carboplatin therapy was not beneficial in the treatment of TCC in the 14 dogs in this study. |
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