Effect of fentanyl on the induction dose and minimum infusion rate of propofol preventing movement in dogs

Objective

To determine the effect of fentanyl on the induction dose of propofol and minimum infusion rate required to prevent movement in response to noxious stimulation (MIR_NM) in dogs.

Study design

Crossover experimental design.

Animals

Six healthy, adult intact male Beagle dogs, mean ± standard deviation 12.6 ± 0.4 kg.

Methods

Dogs were administered 0.9% saline (treatment P), fentanyl (5 μg kg^?1) (treatment PLDF) or fentanyl (10 μg kg^?1) (treatment PHDF) intravenously over 5 minutes. Five minutes later, anesthesia was induced with propofol (2 mg kg^?1, followed by 1 mg kg^?1 every 15 seconds to achieve intubation) and maintained for 90 minutes by constant rate infusions (CRIs) of propofol alone or with fentanyl: P, propofol (0.5 mg kg^?1 minute^?1); PLDF, propofol (0.35 mg kg^?1 minute^?1) and fentanyl (0.1 μg kg^?1 minute^?1); PHDF, propofol (0.3 mg kg^?1 minute^?1) and fentanyl (0.2 μg kg^?1 minute^?1). Propofol CRI was increased or decreased based on the response to stimulation (50 V, 50 Hz, 10 mA), with 20 minutes between adjustments. Data were analyzed using a mixed-model anova and presented as mean ± standard error.

Results

ropofol induction doses were 6.16 ± 0.31, 3.67 ± 0.21 and 3.33 ± 0.42 mg kg^?1 for P, PLDF and PHDF, respectively. Doses for PLDF and PHDF were significantly decreased from P (p < 0.05) but not different between treatments. Propofol MIR_NM was 0.60 ± 0.04, 0.29 ± 0.02 and 0.22 ± 0.02 mg kg^?1 minute^?1 for P, PLDF and PHDF, respectively. MIR_NM in PLDF and PHDF was significantly decreased from P. MIR_NM in PLDF and PHDF were not different, but their respective percent decreases of 51 ± 3 and 63 ± 2% differed (p = 0.035).

Conclusions and clinical relevance

Fentanyl, at the doses studied, caused statistically significant and clinically important decreases in the propofol induction dose and MIR_NM.