| 母体妊娠期应激对后代出生前后下丘脑-垂体-肾上腺轴的影响及其机制 |
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| 引用本文： | 李留安,吴展望,赵茹茜.母体妊娠期应激对后代出生前后下丘脑-垂体-肾上腺轴的影响及其机制[J].动物营养学报,2010,22(5). |
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| 作者姓名： | 李留安 吴展望 赵茹茜 |
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| 作者单位： | 1. 南京农业大学农业部动物生理生化重点开放实验室,南京,210095;天津农学院动物科学系,天津,300384
2. 南京农业大学农业部动物生理生化重点开放实验室,南京,210095 |
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| 基金项目： | 天津市高等学校科技发展基金计划项目，国家自然科学基金重点项目，天津农学院科学研究发展基金计划 |
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| 摘 要： | 动物的生理健康与其正常下丘脑-垂体-肾上腺(hypothalamus-pituitary-adrenocortical,HPA)轴活性是密不可分的.母体妊娠期应激对后代出生前后HPA轴功能及生长发育等均有显著的程序化影响,尤其是对胎儿期HPA轴的影响更大.这种影响主要是通过改变后代上游海马体、下丘脑和垂体中的糖皮质激素受体和盐皮质激素受体表达实现的.下游器官肾上腺皮质作为HPA轴的重要组成部分,也可能是HPA轴程序化的靶器官,有待深入研究.
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| 关 键 词： | 母体妊娠期应激 后代 HPA轴 糖皮质激素 机制 |
Effects of Maternal Stress during Pregnancy on Offspring before and after Birth:Mechanism of Action from a Hypothalamus-Pituitary-Adrenocortical Axis |
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| LI Liuan,WU Zhanwang,ZHAO Ruqian.Effects of Maternal Stress during Pregnancy on Offspring before and after Birth:Mechanism of Action from a Hypothalamus-Pituitary-Adrenocortical Axis[J].Acta Zoonutrimenta Sinica,2010,22(5). |
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| Authors: | LI Liuan WU Zhanwang ZHAO Ruqian |
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| Institution: | LI Liuan1,2 WU Zhanwang1 ZHAO Ruqian1(1.Key Laboratory of Animal Physiology and Biochemistry,Nanjing Agricultural University,Nanjing 210095,China,2.Department of Animal Sciences,Tianjin Agricultural University,Tianjin 300384,China) |
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| Abstract: | Normal hypothalamus-pituitary-adrenocortical (HPA) axis activity is essential for animal physical health.Maternal stress during pregnancy programs HPA axis function,as well as the growth and development of offspring before and after birth.Fetal HPA axis is the most susceptible system responding to maternal stress.These impacts are achieved by alterations in glucocorticoid receptor and mineralocorticoid receptor expressions in hippocampus,hypothalamus and pituitary of the offspring.Adrenal cortex as an impor... |
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| Keywords: | maternal stress during pregnancy offspring HPA axis glucocorticoid mechanism of action |
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