MicroRNA研究概述

MicroRNA(miRNA)是一类真核生物内源性非编码的单链小分子RNA,长约21nt~23nt。越来越多的miRNA在动物细胞和植物组织中发现,这些成熟的小分子RNA是从具有发夹结构的前体miRNA(pre-miRNA)剪切出来,通过与靶mRNA分子互补结合而抑制蛋白翻译或导致mRNA降解,从而调控靶基因的表达。miRNA是一类重要的基因调控子,在机体的基因表达调控、细胞分化和凋亡以及抗病毒防御中发挥重要的作用。深入理解miRNA介导的宿主与病毒之间的相互调节作用,对于阐明病毒的致病机理与制定治疗策略具有深远的意义。

Introduction to MicroRNA Research

MicroRNA (miRNA)is a kind of eukaryote endogenous non-coding small single-strand RNA with a length of 21-23 nucleotides.A growing number of miRNA were found in animal cells and plant tis-sue.These mature small RNA can regulate the expression of target mRNA,suppress protein translation and cause mRNA degradation through binding with complementary target mRNA,which from precursor miRNA(pre-miRNA)with hairpin.MiRNA is an important gene regulator and play an important role in expression and regulation of organism gene,cell differentiation,cellular apoptosis,and antiviral defense.A-mong them,the deep understanding of miRNA mediated matual adjustment between host and virus,which have far-reaching significance to clarify the virus pathogenic mechanism and treatment strategy.