MAPK信号通路对脂肪细胞分化的调控

促分裂原活化的蛋白激酶(MAPK)通路主要包括胞外信号调控激酶(ERK)、p38MAPK和氨基末端蛋白激酶(JNK)三条途径,参与调节细胞增殖、分化、凋亡及细胞间的功能同步等过程,是细胞信号转导方面最为活跃的研究领域之一。研究显示MAPK也参与脂肪细胞的分化调节并发挥重要作用。ERK和p38MAPK信号通路对脂肪细胞分化的调节在不同的实验模型中表现为正调控和负调控两种不同形式;而另一成员JNK能使胰岛素受体底物1的丝氨酸发生磷酸化,进而干扰胰岛素信号,从而抑制骨髓间充质干细胞(BMSCs)的成脂分化,即对脂肪细胞分化发挥负调控作用。论文就MAPK信号通路在脂肪细胞分化中的功能进行综述,为脂类代谢性疾病的诊断和治疗提供参考。

Regulation of MAPK Signaling Pathway in Adipocyte Differentiation

The mitogen activated protein kinase(MAPK) family contains three members: extracellular signal-regulated kinases(ERKs),c-Jun amino-terminal kinases(JNKs),and p38 MAPK.MAPK signaling pathway is one of the most active research areas in cells signal transduction,which involves in the modulation of varied life activities such as cell proliferation,differentiation,apoptosis and cell synchronization.Current studies have shown that MAPK signaling pathway played important regulating roles during human or animals’ adipocyte differentiation.ERK1/2 and p38 MAPK pathways play different roles ie.positive regulation and negative regulation in different experimental models.Another member JNK can promote insulin receptor substrate 1 serine phosphorylated and disturb insulin signaling and thus inhibit adipogenesis differentiation of BMSCs.The results showed JNK plays a negative role during human or animals’ adipocyte differentiation.This article gave a brief overview on the elucidating the functions of MAPK signaling pathway during adipocyte differentiation,and may provide available information for the diagnosis and therapy of metabolic diseases.