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大肠杆菌毒力因子研究概况
引用本文:张越男,张彦明,张怀喜.大肠杆菌毒力因子研究概况[J].动物医学进展,2003,24(4):26-29.
作者姓名:张越男  张彦明  张怀喜
作者单位:1. 西北农林科技大学动物科技学院,陕西杨陵,712100
2. 陕西省延安市畜牧兽医中心,陕西延安,716000
基金项目:杨凌专项基金课题 ( 98C0 3 )
摘    要:致病性大肠杆菌的毒力因子主要有黏附素、毒素、外膜蛋白 ( OMP)及铁转运系统等。在大肠杆菌侵袭宿主组织并引起其发病的过程中 ,这些毒力因子相互协调、发挥作用。文章对毒力因子的致病作用、致病机理、免疫原性及其在疾病防制中的应用几个方面的研究概况作了综述 ,为防制大肠杆菌病、研制新型高效的大肠杆菌疫苗提供了理论依据。另外 ,文章还介绍了近年来已相继研制成功的全菌体疫苗、纯化菌毛疫苗、单价或多价基因工程菌毛疫苗以及重组肠毒素双价基因工程苗、OMP亚单位疫苗等。展现了新型疫苗的研制 ,给防制大肠杆菌病带来了新的前景以及大肠杆菌作为工程菌的应用对畜禽其他疾病防制的推动作用

关 键 词:致病性大肠杆菌  毒力因子  防制  疫苗
文章编号:1007-5038(2003)04-0026-04
修稿时间:2002年12月13

The Research on Virulence Factors of Escherichia coli
ZHANG Yue-nan ,ZHANG Yan-ming ,ZHANG Huai-xi.The Research on Virulence Factors of Escherichia coli[J].Progress In Veterinary Medicine,2003,24(4):26-29.
Authors:ZHANG Yue-nan  ZHANG Yan-ming  ZHANG Huai-xi
Institution:ZHANG Yue-nan 1,ZHANG Yan-ming 1,ZHANG Huai-xi 2
Abstract:Virulence factors of pathogenic Escherichia coli include adhesins, toxins, out membrane proteins,iron-sequestering system and so on. The virulence factors have their own functions in the course of E.coli invading the host. The review emphasized their pathogensis,immunology,and use of prevention and control in disease. It provided a basis of theory for the new vaccine which could reduce the economic losses and improve the living level of the people. In the recent years, studies succeeded in bacterial vaccine, purified fimbriae vaccine, and genetic vaccine. The new kinds of vaccines brought a new prospect in preventing and controlling the disease. At the same time, the use of E.coli as an engineer bacteria promoted a progress in prevention and control in other animal diseases.
Keywords:pathogenic Escherichia coli  virulence factors  prevention and control  vaccine
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