复方氟康唑软膏临床药效试验

为研究复方氟康唑软膏对犬耳道真菌、细菌感染的治疗效果,发犬为试验用动物,采用人工感染和自然感染犬,以耳肤灵为对照,进行42d的临床药效研究。人工感染临床试验结果显示,复方氟康唑软膏和耳肤灵对犬耳道感染均有较好的治疗效果,两者无显著性差异(P>0.05);复方氟康唑软膏推荐剂量组和加倍剂量组对耳道感染的治愈率+显效率均为90%,且与空白对照组相比,差异极显著(P<0.01)。自然感染临床药效试验数据表明,耳肤灵和复方氟康唑软膏对真菌、细菌引起的耳道感染的治愈率+显效率均大于90%,且差异不显著(P>0.05),再次验证了复方氟康唑软膏推荐剂量对犬耳道细菌、真菌感染的治疗效果。表明复方氟康唑软膏推荐剂量(0.5mL/耳,1次/d,连续给药4周)可用于犬耳道细菌、真菌感染的治疗,治疗效果较好,可以在临床中推广使用。

Clinical Efficacy of Compound Fluconazole Ointment

To study the efficacy of compound fluconazole ointment in the treatment of canine auditory canal fungous and bacterial infections.artificially and naturally infected dogs were used in tests,with oridermyl as a control for 42 d clinical efficacy studies.The clinical trial results in artificially infected dogs showed that: compound fluconazole and oridermyl had a better therapeutic effect for canine ear infection,there was no significant difference(P> 0.05);the cure rate of the recommended dose group and the double dose group of compound fluconazole ointment were higher than 90%,and compared with the control group,the difference was extremely significant(P<0.01).The clinical trial data in naturally infected dogs showed the cure rates of compound fluconazole for fungal and bacterial ear infection were higher than 90%,and the difference was not significant(P> 0.05).The recommended dose of compound fluconazole ointment(0.5 mL /ear,1 time/d,continuous administration for 4 weeks) had a better efficacy,and can be used for canine ear bacterial and fungal infections.