肝纤维化动物模型研究进展

肝纤维化是肝损伤后的修复反应,涉及一系列复杂的细胞及分子机制,如何制作和选择与人类肝纤维化相似的动物模型,不仅是深入研究肝纤维化发病机制的重要基础,也是筛选防治肝纤维化药物的有效手段.文章介绍了目前常用的几种肝纤维化动物模型的造模方法,即给实验动物施以不同性质、不同剂量以及不同作用方式的肝毒剂,造成不同类型的肝纤维化模型.通过比较各种方法的致病机理、造模途径、效果、优缺点和各自用途,提出了肝纤维化动物模型的选择依据及研究方向.

Progress on Animal Model of Hepatic Fibrosis

Hepatic fibrosis is the restoration reation after hepatic injury,which involves a series of multiplex mechanisms. How to make and choose the homoplastic animal models is the important base for the research of pathogeny, and also is the effective way to medicines. This paper discussed available methods, pathogenesis, pathway, effect of each current animal model for hepatic fibrosis in detail,and compared the advantages, disadvantages and their different usage among these methods. In the end, it pointed the development trend of this field in the future.