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头孢喹诺的研究进展
引用本文:王付民,陈杖榴.头孢喹诺的研究进展[J].动物医学进展,2004,25(4):50-53.
作者姓名:王付民  陈杖榴
作者单位:华南农业大学广东省兽药研制与安全性评价重点实验室,广东,广州,510642
摘    要:头孢喹诺是动物专用的第 1个第 4代头孢菌素类抗生素 ,其抗菌谱广 ,抗菌活性强 ,对临床分离的各种 G 菌、G-菌的 MIC50 、MIC90 值均较小 ,而且对绿脓杆菌有很强的抗菌活性 ;其动力学特点优良 ,吸收快 ,达峰时间短 ,生物利用度较高 ,可以在肺、乳腺等组织达到较高的组织浓度 ;头孢喹诺毒性低 ,在动物的可食性组织中残留较少 ;国外已广泛应用于猪、牛的呼吸系统感染及奶牛乳房炎的临床治疗。因此 ,在我国兽医临床上具有广阔的应用前景。为了促进其在我国兽医临床上的合理应用、研制与开发 ,现对其抗菌活性、药动学、毒性及残留、临床应用等有关资料进行综述

关 键 词:头孢喹诺  抗菌活性  动力学  毒性及残留
文章编号:1007-5038(2004)04-0050-04
修稿时间:2003年12月10

Advance of Study on Cefquinome
WANG Fu-min,CHEN Zhang-liu.Advance of Study on Cefquinome[J].Progress In Veterinary Medicine,2004,25(4):50-53.
Authors:WANG Fu-min  CHEN Zhang-liu
Abstract:Cefquinome is a fourth-generation cephalosporin, which has been developed solely for veterinary use. It shows potent antibacterial activity against a broad spectrum of bacterial species, to the clinical strains, the MIC_(50) and MIC_(90) is low, furthermore, it has potent activity against Pseudomonas aeruginosa. The antibiotic has better pharmacokinetic characteristic, and it can be absorbed quickly, and can reach the cmax quickly, moreover, it can maintain a high concentration in animal's lungs and mammary glands. It's toxicity is low, and the residue in edible tissue is small. Most important of all, the antibiotic has been extensive use for treatment of cattle and pig against bacterial infections of respiratory tract and the udder. Therefore, the antibiotic has profound prospect in veterinary treatment. In order to promote it's reasonable application and invention in our country, this paper summarized the cefquinome,s antibacterial activity, pharmacokinetics, toxicity and residue, clinical use, so as to provide information for that.
Keywords:cefquinome  veterinary use  antibacterial activity  pharmacokinetics  Toxicity and residue  clinical use
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