| 恩诺沙星微囊在猪体内的药动学及生物利用度研究 |
| |
| 引用本文： | 罗雅劲,孙永学,曾东平,杨大伟,孙坚.恩诺沙星微囊在猪体内的药动学及生物利用度研究[J].动物医学进展,2010,31(10). |
| |
| 作者姓名： | 罗雅劲 孙永学 曾东平 杨大伟 孙坚 |
| |
| 作者单位： | 华南农业大学兽医药理研究室,广东广州,510642 |
| |
| 摘 要： | 为了比较恩诺沙星微囊和原粉在猪体内的药动学特征及生物利用度,试验采用高效液相色谱法(HPLC),将10头健康猪分2组采用正交试验,经灌胃给药后采血、甲醇提取和HPLC分析,所得药时数据用MCPKP计算机程序处理。恩诺沙星微囊和原粉经口服给药后在猪体内的药时数据均符合一级吸收一室模型,主要药动学参数分别为:t1/2Ka1.73 h±0.93 h和0.36 h±0.31 h(P0.01);Tmax5.69 h±1.68 h和2.04 h±1.06 h(P0.01);t1/2Ke16.53 h±5.23 h和10.17 h±1.87 h(P0.01);Cmax1.71μg/mL±0.47μg/mL和2.51μg/mL±0.45μg/mL(P0.01);AUC为每小时51.98μg/mL±16.08μg/mL和40.58μg/mL±6.40μg/mL;微囊的相对生物利用度为128%。说明恩诺沙星微囊口服给药吸收较慢但完全,达峰时间较长,消除缓慢。
|
| 关 键 词： | 恩诺沙星微囊 药动学 生物利用度 猪 |
Pharmacokinetics and Bioavailability of Enrofloxacin Microcapsules in Pigs |
| |
| LUO Ya-jin,SUN Yong-xue,ZENG Dong-ping,YANG Da-wei,SUN Jian.Pharmacokinetics and Bioavailability of Enrofloxacin Microcapsules in Pigs[J].Progress In Veterinary Medicine,2010,31(10). |
| |
| Authors: | LUO Ya-jin SUN Yong-xue ZENG Dong-ping YANG Da-wei SUN Jian |
| |
| Institution: | LUO Ya-jin,SUN Yong-xue,ZENG Dong-ping,YANG Da-wei,SUN Jian (Laboratory of Veterinary Phamacology,South China Agricultural University,Guangzhou,Guangdong,510642,China) |
| |
| Abstract: | The plasma pharmacokinetics and bioavailability of enrofloxacin microcapsules and enrofloxacin in pigs were studied using HPLC method.Ten healthy pigs were assigned to two groups and dosed the two drugs following a single oral administration,respectively.Blood samples were collected at different intervals and extracted by methanol.Finally,the samples were detected by HPLC and were analysed using the MCPRP software package.The two drugs' concentration-time data were both fitted to a one-compartment open mode... |
| |
| Keywords: | enrofloxacin microcapsules pharmacokinetics bioavilability pigs |
| 本文献已被 CNKI 万方数据 等数据库收录！ |
|
