| 细菌人工染色体载体系统在反向遗传学中的应用研究进展 |
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| 引用本文： | 丛彦龙,孙玉章,丁壮.细菌人工染色体载体系统在反向遗传学中的应用研究进展[J].动物医学进展,2009,30(8):81-84. |
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| 作者姓名： | 丛彦龙 孙玉章 丁壮 |
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| 作者单位： | 吉林大学畜牧兽医学院,吉林长春,130062 |
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| 基金项目： | 国家自然科学基金资助(30771606);;吉林大学农学部引进人才科研启动基金(4305050102B6) |
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| 摘 要： | 细菌人工染色体是近十几年来发展起来的一种新型DNA克隆载体系统,具有操作简单、遗传稳定、容量大等明显的优势。论文主要综述了细菌人工染色体载体系统在基础研究、基因治疗及病毒载体疫苗等反向遗传学方面的研究进展。
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| 关 键 词： | 细菌人工染色体（BAC） 载体系统 反向遗传学 |
Progress on Application of Bacterial Artificial Chromosome System in the Reverse Genetics |
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| CONG Yan-long,SUN Yu-zhang,DING Zhuang.Progress on Application of Bacterial Artificial Chromosome System in the Reverse Genetics[J].Progress In Veterinary Medicine,2009,30(8):81-84. |
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| Authors: | CONG Yan-long SUN Yu-zhang DING Zhuang |
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| Institution: | College of Animal Science and Veterinary Medicine;Jilin University;Changchun;Jilin;130062;China |
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| Abstract: | Reverse genetics system is an excellent platform to research the construction and function of viruses by gene recombination,mosaicism,and mutation that may interfere with replication,assembly and release of viruses.The bacterial artificial chromosome(BAC) clone provides a stable reverse genetics system for manipulation and study of viral genome.The recent use of BAC technology has opened up new avenues for reverse genetics of some viruses in basic research,gene therapy,and also in vector and vaccine develop... |
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