氯霉素残留的危害及其检测方法

氯霉素属广谱抗生素 ,曾在畜牧业中广为应用。但氯霉素有较强的副作用和毒性作用 ,如果氯霉素在食用动物中残留 ,可通过食物链传给人类 ,长期微量摄入氯霉素 ,不仅使人体肠道正常菌群失调 ,而且还会引起多种疾病 ,对人类的健康造成危害。世界上许多国家禁止此药用于生产食品动物 ,并规定了在畜产品中氯霉素不得检出。对于氯霉素的残留 ,存在多种检测方法 ,不同的检测方法具有不同的检出限。检测限问题已成为关注的焦点 ,发达国家对检出限的要求越来越严格

Harms and Detecting Methods of Chloramphenicol Residue

Chloramphenicol(CAP)is a broad spectrum antibiotic that had ever been widely used at the therapeutic doses for treatment of infections in animal and humans, but several years of clinical use has produced a significant amount of evidence relative to the toxic effects of Chloramphenicol on humans.There is a potential for misuse in animals because chloramphenicol is effective in the animal therapy and low cost, chloramphenicol residue may be present in the tissue of treated food producing animals thereby posing a heath risk to consumers. In one hand, Chloramphenicol residue in food can help to promote the evolution of bacteria to become resistant to many antibiotics,in another hand,they can cause serious acute reactions,including aplastic anemia. Consequently,many countries in the world don't permit its use in food producing animals,and stipulate that the residues of chloramphenicol can't be detected in the food products of animal origin.There are many methods for detection of chloramphenicol,but different methods for separation and detection of chloramphenicol appear to have different limit of detection. So the limit of detection of chloramphenicol becomes a global concern.this paper is focused on the harms and detecting methods of chloramphenicol residue in the food products of animal origin.